β-Selective synthesis of 2′-deoxynucleosides by the coupling of 2-deoxy-1-thio-D-threo-pentofuranosides with silylated thymine

DOI: 10.1016/S0040-4039(00)92229-9

Source and publish data:

Tetrahedron Letters p. 2515 - 2516 (1992)

Update date:2022-08-04

Topics:

Authors:

Sugimura, Hideyuki

Sujino, Keiko

Osumi, Kenji

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Article abstract of DOI:10.1016/S0040-4039(00)92229-9

The coupling of the 3,5-O-isopropylidene derivative of phenyl 2-deoxy-1-thio-D-threo-pentofuranoside with silylated thymine in the presence of N-bromosuccinimide yielded 1-(2-deoxy-β-D-threo-pentofuranosyl)thymine with highly anomeric selectivity.

Full text of DOI:10.1016/S0040-4039(00)92229-9

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Product name:1-(3,5-O-Benzylidene-2-deoxy-α-D-threo-pentofuranosyl)thymine

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