No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides

DOI: 10.1039/c3cc37795d

Source and publish data:

Chemical Communications p. 2151 - 2153 (2013)

Update date:2022-08-04

Topics:

Authors:

Chun, Joong-Hyun

Morse, Cheryl L.

Chin, Frederick T.

Pike, Victor W.

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Article abstract of DOI:10.1039/c3cc37795d

No-carrier-added [¹⁸F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [¹⁸F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[¹⁸F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel ¹⁸F-labeling synthons and PET radiotracers.

Full text of DOI:10.1039/c3cc37795d

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