Asymmetric Michael additions of Grignard reagents to cinnamamides deriving from N-alkyl (R)-(-)-2-aminobutan-1-ol

Article abstract of DOI:10.1016/S0957-4166(00)82287-9

Reaction of cinnamoyl chloride with various N-alkyl derivatives of (R)-(-)-2-aminobutan-1-ol (a readily available reagent) afforded the corresponding cinnamamides. Michael additions of Grignard reagents to the latter, followed by acidic hydrolysis, yielde