Methylene acetal formation from 1,2- and 1,3-diols using an O, S -acetal, 1,3-dibromo-5,5-dimethylhydantoin, and BHT

Article abstract of DOI:10.1021/jo4000256

A mild and efficient method for formation of methylene acetals from 1,2- and 1,3-diols using methoxymethylphenylsulfide, 1,3-dibromo-5,5- dimethylhydantoin (DBDMH), and dibutylhydroxytoluene (BHT) is described. The use of BHT in this process suppresses side reactions and enables high-yielding formation of methylene acetals of various diols, including carbohydrate-type substrates.

Full text of DOI:10.1021/jo4000256

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Note
Methylene Acetal Formation from 1,2- and 1,3-Diols Using
an O,S-acetal, 1,3-Dibromo-5,5-dimethylhydantoin and BHT
Tomohiro Maegawa, Yasuyuki Koutani, Kazuki Otake, and Hiromichi Fujioka
J. Org. Chem., Just Accepted Manuscript • DOI: 10.1021/jo4000256 • Publication Date (Web): 14 Feb 2013
Downloaded from http://pubs.acs.org on February 17, 2013
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Methylene Acetal Formation from 1,2ꢀ and 1,3ꢀDiols Using
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an O,Sꢀacetal, 1,3ꢀDibromoꢀ5,5ꢀdimethylhydantoin and
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BHT
Tomohiro Maegawa, Yasuyuki Koutani, Kazuki Otake, and Hiromichi Fujioka*
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565ꢀ0871, Japan
fujioka@phs.osakaꢀu.ac.jp
ABSTRACT: A mild and efficient method for formation of methylene acetals from 1,2ꢀ and 1,3ꢀdiols using
methoxymethylphenylsulfide, 1,3ꢀdibromoꢀ5,5ꢀdimethylhydantoin (DBDMH) and dibutylhydroxytoluene
(BHT) is described. The use of BHT in this process suppresses side reactions and enables high yielding
formation of methylene acetals of various diols, including carbohydrateꢀtype substrates.
Protection of diols is a fundamental reaction in organic synthesis. Among the protection groups that have been
developed to date for this purpose,1 those that involve acetal/ketalꢀtype moieties are preferred. For example,
the acetonide moiety is commonly utilized for diol protection owing to its stability under strongly basic and
neutral conditions and its ready cleavability using weak acids. The benzylidene acetal group is also used for
protection of diols because its deprotection can be promoted by using conditions similar to those employed for
acetonides as well as by employing simple hydrogenolysis.
Although it is known to be robust under a wide range of conditions, including those that are strongly basic and
moderately acidic, the methylene acetal group has not been used often for diol protection. The main reason for
this lies in the fact that formation of methylene acetals is generally conducted under strongly acidic or basic
conditions and removal of this group typically requires harsh conditions. Therefore, the development of mild
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and facile methylene acetal protection and deprotection protocols is highly desirable. As part of an
investigation aimed at this goal, we recently developed a novel, mild method for deprotection of methylene
acetals.2 Specifically, we observed that use of a combination of TMSOTf (or TESOTf) and 2,2’ꢀbipyridyl
effectively converts methylene acetals to the corresponding 2,2’ꢀbipyridilium salts, which then are
transformed to various types of diol derivatives, including free diols, by treatment with H2O or CH3OH.
Various functional groups, even those that are acidꢀlabile, remain unreactive under the deprotection
conditions.
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In contrast, procedures for forming methylene acetals have not been fully developed and some of those
described thus far suffer from low efficiencies. The existing methods for methylene acetal generation rely
either on acid catalyzed acetalization or CH2Br2 promoted Williamson ether synthesis reactions.3 Other
methods developed for producing methylene acetals utilize DMSO/POCl3 or SOCl2,4
DMSO/Nꢀbromosuccinimide (NBS),5 DMSO/Br2,6 DMSO/TMSCl(/Et3N),7,8 TMSOTf/2,6ꢀlutidine/
(CH3O)2CH2,9 1,1ꢀthiocarbonyldiimidazole/triphenyltin hydride/AIBN,10 DMSO/MeOTCT.11 Some of these
procedures have been applied in natural product synthesis,7b,8,9 and one, the Guiso method (DMSO/POCl3 or
SOCl2),4 is both mild and high yielding and, consequently, it is applicable to carbohydrate substrates. However,
in general the yields of most processes producing methylene acetals from corresponding diols are only
moderate and their substrate scopes have not been fully explored.
In continuing studies in this area, we investigated a new procedure for forming methylene acetals. Methods
for the direct conversion of thioacetals (S,Sꢀacetal) and O,Sꢀacetals to acetals (O,Oꢀacetal) under oxidative
conditions have been described in the context of new carbonyl protection protocols.12 We hypothesized that
the methylene unit transfer strategy employed in these processes could be applied to reactions between
thioacetals or O,Sꢀacetals and diols. Our plan was to employ a combination of simple 1,3ꢀdithianes or
O,Sꢀacetals as methylene sources and halonium reagents as oxidants in processes that convert diols to
methylene acetals. In a study designed to test the feasibility of this strategy, we first investigated suitable
methylene sources in reactions of diol 1a that utilize 1,3ꢀdibromoꢀ5,5ꢀdimethylhydantoin (DBDMH) as the
oxidant (Table 1, entries 1ꢀ4). The results showed that 1,3ꢀdithiane does not participate in this reaction (entry
1) but that O,Sꢀacetals serve as methylene sources in reactions that generate methylene acetal 2a. In these
processes, the commercially available methoxymethylphenylsulfide was found to be the best methylene donor
(entry 2). In addition, we observed that only a trace amount of a methylene acetal is produced when
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2ꢀmethoxymethylthiopyridine13 is used for this purpose (entry 4).
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Next, a study was conducted to explore several halonium oxidants for the methylene acetal forming reaction
of diol 1a promoted by methoxymethylphenylsulfide (Table 1, entries 5ꢀ10). The observations demonstrated
that all of halonium sources promote this reaction but with different rates. For example, the reaction using
Nꢀchlorosuccinimide (NCS) requires 24 h for completion but the yield of the process is high (89%) (entry 5).
NꢀIodosuccinimide (NIS) was observed to be the most reactive oxidant (20 min for completion) but the yield
of the reaction is slightly lower (entry 6). Processes promoted by both NBS and DBDMH take place
reasonably fast and in high yields (entries 7 and 8), and in contrast to NBS, increasing the amount of DBDMH
lowers the reaction time and increases the yield (entries 9 and 10). The findings suggested that DBDMH is an
ideal oxidant to be employed in further studies of the methylene acetal forming reaction.
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Table 1. Methylene acetal 2b formation by reactions of diol 1a with S,Sꢀ or O,Sꢀacetals and oxidants.a
entry
S,S or O,Sꢀacetal
oxidant
DBDMH
DBDMH
DBDMH
DBDMH
NCS
reagent equivalentb
time
5 h
yield (%)c
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2
3
4
5
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7
8
9
1,3ꢀdithiane
1.5
1.5
1.5
1.5
1.2
1.2
1.2
1.2
1.5
1.5
0
0.5 h
1 h
93
< 75d
trace
88
1 h
24 h
20 min
1 h
NIS
82
NBS
89
DBDMH
NBS
1 h
89
1 h
85
10
DBDMH
30 min
93
a
Reactions were carried out using the same amounts of the S,Sꢀ or O,Sꢀacetal and oxidants (1.5 or 1.2 equiv)
at rt in CH3CN. b Equivalent of DBDMH is based on molecule, not based on bromine atom. c Isolated yields. d
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Reaction afforded an inseparable mixture of products.
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The scope of the new protection methodology was probed utilizing diols containing functional groups other
than a benzyl ether, including a benzoate and acetate ester (1b and 1c). In both cases, reactions take place
smoothly to afford the corresponding methylene acetals 2b and 2c in high yields (Scheme 1). However,
reaction of the nonꢀfunctionalized diol 2d occurs with low efficiency (36%) and the bromoformate 3 is also
generated (20%) as a byꢀproduct.
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Scheme 1. Methylene acetal formation of diols promoted by PhSCH2OCH3 and DBDMHa
a Equivalent of DBDMH is based on molecule, not based on bromine atom.
A plausible mechanism for the methylene acetal forming reaction is shown in Scheme 2. In the pathway,
oxidation at the sulfur center in PhSCH2OCH3 by a bromonium ion activates loss of the phenylthioꢀmoiety to
form an oxonium ion that reacts with the diol to form a monoꢀMOM ether intermediate 4. Cyclization of the
monoꢀMOM monoꢀalcohol 4 then generates the methylene acetal. In fact, we observed that a regioisomeric
mixture of monoꢀMOM protected diols 4 reacts to form a single methylene acetal in quantitative yield under
the reaction conditions.14 Evidence supporting the proposed formation of bromoformate 3 through secondary,
HanessianꢀHullarꢀtype bromination reaction15 of initial formed methylene acetal came from the finding
methylene acetal 2d reacts to form 3 and the bromoalcohol hydrolysis product under the conditions employed.
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Scheme 2. Plausible mechanism for the methylene acetal and bromoformate forming reactions
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Based on the thought that the initial step of the HanessianꢀHullarꢀtype reaction is a radical process,16 we
speculated that the presence of the radical scavenger dibutylhydroxytoluene (BHT) in the reaction mixture
would inhibit the undesirable side reaction and lead to improved product yields. Indeed, reactions of a variety
of diols 1d-l (Table 2) carried out using 1.5 equiv of PhSCH2OCH3, 1.5 equiv of DBDMH and 1.5 equiv of
BHT at rt in CH3CN were found to generate the respective methylene acetals in high yields. Notably, the
styreneꢀderived diol 1h as well as internal 1,2ꢀdiols containing sterically crowded secꢀand tertꢀhydroxy groups
(1i and 1j) are transformed to the corresponding methylene acetals under these conditions (entries 5ꢀ7). The
method is also applicable to protection of the 1,3ꢀdiol 1k, whose reaction affords a 1,3ꢀdioxane in 85% yield
(entry 8). Moreover, triol 1l is also converted to the methylene acetal 2l, leaving the terminal hydroxyl group
intact (60%) (entry 9).
Table 2. Substrate scope for the methylene acetal forming reaction promoted by PhSCH2OCH3, DBDMH and
BHT.a
entry
1
substrate
time (h)
20 min
yield (%)b
98 (2d)
2
50 min
94 (2e)
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1 h
92 (2f)
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quant (2g)
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76 (2j)
6c
7 c
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60 (2l)
OH
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OH
HO
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1l
a Reactions were carried out using 1.5 equiv of PhSCH2OCH3, 1.5 equiv of DBDMH and 1.5 equiv of BHT at
b
c
rt in CH3CN. Equivalent of DBDMH is based on molecule, not based on bromine atom. Isolated yields. 2
equiv of each reagent was used.
Finally, we have shown that the protection strategy is also applicable to the sugar substrate 5, which reacts to
produce the corresponding methylene acetal 6 in 85% yield. Importantly, the use of conventional methods,
such as those employing acid and base conditions, are not as effective for promoting methylene acetal
generation with this substrate (Scheme 3).
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Scheme 3. Methylene acetal formation of sugarꢀtype substrate.a
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a Equivalent of DBDMH based on molecule, not based on bromine atom.
In summary, the study described above has led to the development of a novel, mild method, which uses a
combination of PhSCH2OCH3, DBDMH and BHT, for converting 1,2ꢀ and 1,3ꢀdiols to methylene acetals.
Noteworthy features of the new method, associated with high yields, short reaction times and functional group
tolerance, should make the methylene acetal procedure a useful method for diol protection.
Experimental Section
General consideration
Infrared spectra (IR) were recorded using a diffuse reflectance measurement of samples dispersed in KBr
powder. 1H NMR and 13C NMR spectra were recorded in CDCl3 with tetramethylsilane as an internal standard.
Data are reported as follows: chemical shift in ppm (δ), multiplicity (s = singlet, d = doublet, t = triplet, q =
quartet, m = multiplet, brs = broad singlet), coupling constant (Hz) and integration. Mass spectra were
obtained with ionization voltages of 70 eV using quadrupole mass spectrometer. Column chromatography and
TLC were carried out on Merck Silica gel 60 (230ꢀ400 mesh), Kanto kagaku Silica gel 60N (40ꢀ50 ꢀm,
spherical, neutral), and Merck silica gel F254 plates (0.25 mm), respectively. The commercially available
reagents were used without further purification. The equivalent of DBDMH indicated whole molecules, not
bromine atom in DBDMH. Compound 1d, 9, 2k, and nꢀdecylthiol are commercially available and compounds
1a,2a 1b,2a 1c,17 1f,18 1g,2a 1h,19 1j,20 1k,2a 1l,2a 5,21 2a,2a 2b,2a 2d,22 2g,2a 2h,23 2l,2a and 724 are known
compound.
General procedure for methylene acetal 2a formation by reactions of diol 1a with S,S- or O,S-acetals
and oxidants (Table 1)
An oxidant (1.5 or 1.2 equiv.) was added to a solution of diol 1a (1.0 equiv.) and S,Sꢀ or O,Sꢀacetal (1.5 or 1.2
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equiv.) in CH3CN (0.2 M) at room temperature under N2. After 1a was consumed (checking by TLC), 10%
aqueous KOH (2 mL) was added to the reaction mixture and the mixture was extracted with CH2Cl2 (30 mL ×
3). The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo. The residue was
subjected to flash column chromatography (SiO2, hexanes→hexanes/AcOEt = 15/1) affording methylene
acetal 2a.
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11-(benzyloxy)undecane-1,2-diol (1a)2a
White solid; 1H NMR (300 MHz, CDCl3) δ: 1.22ꢀ1.46 (m, 14H), 1.59ꢀ1.64 (m, 2H), 1.72 (brs, 2H), 3.38ꢀ3.46
(m, 3H), 3.61ꢀ3.66 (m, 2H), 4.48 (s, 2H), 7.24ꢀ7.33 (m, 5H).
4-[9-(benzyloxy)nonyl]-1,3-dioxolane (2a)2a
Colorless oil; 1H NMR (400 MHz, CDCl3) δ: 1.29ꢀ1.61 (m, 16H), 3.41ꢀ3.48 (m, 3H), 3.95ꢀ3.98 (m, 2H), 4.50
(s, 2H), 4.87 (s, 1H), 5.02 (s, 1H), 7.26ꢀ7.35 (m, 5H).
Synthesis of decyl(methoxymethyl)sulfane
decyl(methoxymethyl)sulfane
Chloromethyl methyl ether (2 mL, 26.3 mmol) was added to the solution of nꢀdecylthiol (2 mL, 9.6 mmol)
and Nꢀethyldiisopropylamine (4 mL, 23.2 mmol) in CH2Cl2 (20 mL) at 0 °C under N2. After the starting
material was consumed (48 h) (monitored by TLC), the reaction mixture was concentrated in vacuo. The
residue was subjected to flash column chromatography (SiO2, hexanes/AcOEt = 5/1) affording
decyl(methoxymethyl)sulfane as colorless oil (1.65 g, 79%); IR (KBr): 2853, 1971 cmꢀ1; 1H NMR (300 MHz,
CDCl3) δ: 0.86 (t, J = 6.7 Hz, 3H), 1.18ꢀ1.41 (m, 14H), 1.53ꢀ1.61 (m, 2H), 2.57 (t, J = 7.4 Hz, 2H), 3.33 (s,
3H), 4.61 (s, 2H); 13C NMR (75 MHz, CDCl3) δ: 14.1, 22.7, 28.9, 29.2, 29.3, 29.51, 29.53, 29.9, 30.9, 31.9,
55.6, 75.4; HRMS (EI) calcd for C12H26OS (M+) 218.1704, found 218.1715.
General procedure for the methylene acetal formation of diols promoted by PhSCH2OCH3 and
DBDMH (Scheme 1)
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DBDMH (1.5 equiv.) was added to a solution of diol 1 (1.0 equiv.) and methoxymethyl phenyl sulfide (1.5
equiv.) in CH3CN (0.2 M) at room temperature under N2. After the substrate 1 was consumed (monitored by
TLC), satd. aqueous NaHCO3 (2 mL) was added to the reaction mixture and the mixture was extracted with
CH2Cl2 (30 mL × 3). The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo.
The residue was subjected to flash column chromatography (SiO2) affording methylene acetal.
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2a: According to the general procedure, the treatment of diol 1a (63.0 mg, 0.213 mmol) with DBDMH (92.0
mg, 0.320 mmol) and methoxymethyl phenyl sulfide (47.0 ꢁL, 0.320 mmol), for 0.5 h afforded 2a (60.4 mg,
93%). Eluent; hexanes→hexanesꢀAcOEt (15/1).
2b: According to the general procedure, the treatment of diol 1b (60.0 mg, 0.195 mmol) with DBDMH (83.2
mg, 0.292 mmol) and methoxymethyl phenyl sulfide (43.0 ꢁL, 0.292 mmol), for 0.5 h afforded 2b (56.7 mg,
91%). Eluent; hexanes→hexanesꢀAcOEt (15/1).
10,11-dihydroxyundecyl benzoate (1b)2a
White solid; 1H NMR (400 MHz, CDCl3) δ: 1.29ꢀ1.42 (m, 14H), 1.71ꢀ1.78 (m, 2H), 1.82 (brs, 1H), 1.97 (brs,
1H), 3.39ꢀ3.44 (m, 1H), 3.62ꢀ3.70 (m, 2H), 4.29 (t, J = 6.9 Hz, 2H), 7.40ꢀ7.44 (m, 2H), 7.51ꢀ7.56 (m, 1H),
8.01ꢀ8.04 (m, 2H).
9-[1,3-dioxolan-4-yl]nonyl benzoate (2b)2a
Colorless oil; 1H NMR (300 MHz, CDCl3) δ: 1.23ꢀ1.78 (m, 16H), 3.35ꢀ3.42 (m, 1H), 3.91ꢀ3.97 (m, 2H), 4.29
(t, J = 6.5 Hz, 2H), 4.83 (s, 1H), 4.99 (s, 1H), 7.38ꢀ7.43 (m, 2H), 7.50ꢀ7.55 (m, 1H), 8.00ꢀ8.03 (m, 2H).
2c: According to the general procedure, the treatment of diol 1c (69.7 mg, 0.282 mmol) with DBDMH (123.0
mg, 0.430 mmol) and methoxymethyl phenyl sulfide (63.0 ꢁL, 0.430 mmol), for 1 h afforded 2c (68.0 mg,
93%). Eluent; hexanes→hexanesꢀAcOEt (10/1).
10,11-dihydroxyundecyl acetate (1c)17
1
White solid; H NMR (400 MHz, CDCl3) δ: 1.22ꢀ1.46 (m, 14H), 1.56ꢀ1.63 (m, 2H), 2.03 (s, 3H), 3.40ꢀ3.44
(m, 1H), 3.63ꢀ3.70 (m, 2H), 4.03 (t, J = 6.9 Hz, 2H).
9-[1,3-dioxolan-4-yl]nonyl acetate (2c)
1
Colorless oil; IR (KBr): 2932, 2253, 1732 cmꢀ1; H NMR (400 MHz, CDCl3) δ: 1.21ꢀ1.64 (m, 16H), 2.01 (s,
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3H), 3.38 (t, J = 10.1 Hz, 1H), 3.92ꢀ3.96 (m, 2H), 4.01 (t, J = 6.9 Hz, 2H), 4.83 (s, 1H), 4.98 (s, 1H); 13C
NMR (100 MHz, CDCl3) δ: 21.0, 25.77, 25.83, 28.5, 29.2, 29.34, 29.37, 29.48, 33.0, 64.6, 69.6, 76.2, 94.7,
171.2; HRMS (FAB) calcd for C14H27O4 (M++H) 259.1909, found 259.1911.
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2d: According to the general procedure, the treatment of diol 1d (106.6 mg, 0.527 mmol) with DBDMH
(226.0 mg, 0.791 mmol) and methoxymethyl phenyl sulfide (116.0 ꢁL, 0.791 mmol), for 20 min afforded 2d
(40.2 mg, 36%) and 3 (30.1mg, 20%). Eluent; hexanes→hexanesꢀEt2O (100/1→50/1).
4-decyl-1,3-dioxolane (2d)22
Yellow oil;1H NMR (300 MHz, CDCl3) δ: 0.85 (t, J = 6.7 Hz, 3H), 1.15ꢀ1.65 (m, 18H), 3.36ꢀ3.42 (m, 1H),
3.90ꢀ3.99 (m, 2H), 4.84 (s, 1H), 4.99 (s, 1H).
1-bromododecan-2-yl formate (3)
Yellow oil; IR (KBr): 2926, 2255, 1728 cmꢀ1; 1H NMR (400 MHz, CDCl3): 0.85 (t, J = 6.6 Hz, 3H), 1.20ꢀ1.33
(m, 16H), 1.66ꢀ1.72 (m, 2H), 3.41ꢀ3.52 (m, 2H), 5.10ꢀ5.23 (m, 1H), 8.09 (s, 1H);13C NMR (75 MHz, CDCl3)
δ: 14.1, 22.7, 24.9, 29.22, 29.29, 29.37, 29.47, 29.54, 31.9, 32.5, 33.7, 72.4, 160.3 ; HRMS (FAB) calcd for
C13H25BrNaO2 (M++Na) 315.0936, found 315.0907.
General procedure for the methylene acetal forming reaction promoted by PhSCH2OCH3, DBDMH and
BHT (Table 2)
DBDMH (1.5 equiv.) was added to a solution of diol 1 (1.0 equiv.), BHT (1.5 equiv.) and methoxymethyl
phenyl sulfide (1.5 equiv.) in CH3CN (0.2 M) at room temperature under N2. After 1 was consumed
(monitored by TLC), 10% aqueous KOH (2 mL) was added to the reaction mixture and the mixture was
extracted with Et2O (30 mL × 3). The combined organic layers were dried over Na2SO4, filtered and
concentrated in vacuo. The residue was subjected to flash column chromatography (SiO2) affording methylene
acetal 2.
Entry 1: According to the general procedure, the treatment of diol 1d (101.1 mg, 0.500 mmol) with DBDMH
(214.4 mg, 0.750 mmol), BHT (165.3 mg, 0.750 mmol) and methoxymethyl phenyl sulfide (110.0 ꢁL, 0.750
mmol), for 20 min afforded 2d (105.0 mg, 98%). Eluent; hexanes→hexanes/Et2O = (50/1).
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Entry 2: According to the general procedure, the treatment of diol 1e (83.0 mg, 0.372 mmol) with DBDMH
(160.0 mg, 0.558 mmol), BHT (123.0 mg, 0.558 mmol) and methoxymethyl phenyl sulfide (82.0 ꢁL, 0.558
mmol), for 50 min afforded 2e (82.0 mg, 94%). Eluent; hexanes→hexanes/Et2O = (15/1).
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Synthesis of 1e
4-(9-chlorononyl)-2,2-dimethyl-1,3-dioxolane (8)
MsCl (0.2 mL, 2.2 mmol) was added to the solution of 724 (514.0 mg, 2.1 mmol) and triethylamine (0.4 mL,
2.2 mmol) in DMF (5 mL) at 0 ºC under N2 and the reaction mixture was stirred at room temperature. After 7
was consumed (42 h) (monitored by TLC), LiCl (350.0 mg, 8.2 mmol) was added to the reaction mixture at
room temperature under N2 and the resulting solution was stirred at the same temperature for 8 h. Then H2O
was added to the reaction mixture and the solution was extracted with CH2Cl2 (30 mL × 3). The combined
organic layers were dried over Na2SO4, filtered and concentrated in vacuo. The residue was subjected to flash
column chromatography (SiO2, hexanes/AcOEt = 10/1) affording 8 as colorless oil (347 mg, 63%); IR (KBr):
2930, 2251 cmꢀ1; H NMR (300 MHz, CDCl3) δ: 1.27ꢀ1.79 (m, 22H), 3.45ꢀ3.53 (m, 3H), 3.98ꢀ4.07 (m, 2H);
1
13C NMR (75 MHz, CDCl3) δ: 25.7, 26.8, 27.0, 28.8, 29.3, 29.4, 29.6, 32.6, 33.6, 45.2, 69.5, 76.1, 108.6;
HRMS (FAB) calcd for C14H28ClO2 (M++H) 263.1778, found 263.1785.
11-chloroundecane-1,2-diol (1e)
A solution of 8 (236.0 mg, 0.898 mmol) in 1N HCl aq. (1 mL) and THF (1 mL) was stirred at room
temperature. After 8 was consumed (90 h) (monitored by TLC), sat. aqueous NaHCO3 was added to the
reaction mixture and the resulting solution was extracted with AcOEt (30 mL × 3). The combined organic
layers were dried over Na2SO4, filtered and concentrated in vacuo. The residue was subjected to flash column
chromatography (SiO2, hexanes/AcOEt = 1/1) affording 1e as white solid (181.9 mg, 91%); m.p. 49 ºC; IR
(KBr): 3342, 2930, 2251 cmꢀ1; H NMR (400 MHz, CDCl3) δ: 1.21ꢀ1.50 (m, 14H), 1.69ꢀ1.80 (m, 2H), 2.40
1
(brs, 2H), 3.38ꢀ3.42 (m, 1H), 3.49ꢀ3.52 (m, 2H), 3.61ꢀ3.67 (m, 2H);13C NMR (100 MHz, CDCl3) δ: 25.5, 26.8,
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28.8, 29.3, 29.4, 29.6, 32.6, 33.1, 45.2, 66.8, 72.3; HRMS (FAB) calcd for C11H24ClO2 (M++H) 223.1465,
found 223.1481.
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4-[9-chlorononyl]-1,3-dioxolane (2e)
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Brown oil; IR (KBr): 2930, 2253, 1682 cmꢀ1; 1H NMR (400 MHz, CDCl3) δ: 1.22ꢀ1.78 (m, 16H), 3.39 (t, J =
11.6 Hz, 1H), 3.50 (t, J = 6.9 Hz, 2H), 3.94ꢀ3.96 (m, 2H), 4.84 (s, 1H), 4.99 (s, 1H); 13C NMR (100 MHz,
CDCl3) δ: 25.8, 26.8, 28.8, 29.3, 29.4, 29.5, 32.6, 33.0, 45.2, 69.6, 76.3, 94.8; Anal. calcd for C12H23ClO2: C,
61.39; H, 9.87; Cl, 15.10, found: C, 61.52; H, 9.92; Cl, 15.05.
Entry 3: According to the general procedure, the treatment of diol 1f (64.2 mg, 0.241 mmol) with DBDMH
(103.4 mg, 0.362 mmol), BHT (79.7mg, 0.362 mmol) and methoxymethyl phenyl sulfide (47.0 ꢁL, 0.362
mmol), for 1 h afforded 2f (61.8 mg, 92%). Eluent; hexanes→hexanes/Et2O = (50/1).
11-bromoundecane-1,2-diol (1f)18
1
White solid; IR (KBr): 3325, 2928, 2251, 1794 cmꢀ1; H NMR (400 MHz, CDCl3) δ: 1.28ꢀ1.42 (m, 14H),
1.79ꢀ1.87 (m, 3H), 1.95 (d, J = 4.6 Hz, 1H), 3.37ꢀ3.44 (m, 3H), 3.62ꢀ3.70 (m, 2H); 13C NMR (100 MHz,
CDCl3) δ: 25.5, 28.1, 28.7, 29.3, 29.4, 29.5, 32.8, 33.1, 34.1, 66.8, 72.3.
4-(9-bromononyl)-1,3-dioxolane (2f)
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Yellow oil; IR (KBr): 2930, 2251, 1726 cmꢀ1; H NMR (400 MHz, CDCl3) δ: 1.24ꢀ1.42 (m, 14H), 1.78ꢀ1.85
(m, 2H), 3.36ꢀ3.39 (m, 3H), 3.92ꢀ3.95 (m, 2H), 4.83 (s, 1H), 4.98 (s, 1H); 13C NMR (100 MHz, CDCl3) δ:
25.8, 28.1, 28.7, 29.26, 29.34, 29.5, 32.8, 32.9, 34.0, 69.6, 76.2, 94.7; HRMS (FAB) calcd for C12H24BrO2
(M++H) 279.0960, found 279.0942.
Entry 4: According to the general procedure, the treatment of diol 1g (86.0 mg, 0.516 mmol) with DBDMH
(221.3 mg, 0.774 mmol), BHT (170.5mg, 0.774 mmol) and methoxymethyl phenyl sulfide (114.0 ꢁL, 0.774
mmol), for 30 min afforded 2g (99.5 mg, quant.). Eluent;. hexanes→hexanes/Et2O = (50/1).
4-phenylbutane-1,2-diol (1g)2a
White solid; 1H NMR (400 MHz, CDCl3) δ: 1.74ꢀ1.84 (m, 2H), 2.21 (t, J = 5.5 Hz, 1H), 2.41 (d, J = 4.1 Hz,
1H), 2.69ꢀ2.88 (m, 2H), 3.46ꢀ3.52 (m, 1H), 3.66ꢀ3.78 (m, 2H), 7.20ꢀ7.33 (m, 5H).
4-phenethyl-1,3-dioxolane (2g)2a
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Yellow oil; 1H NMR (400 MHz, CDCl3) δ: 1.81ꢀ1.90 (m, 1H), 1.95ꢀ2.04 (m, 1H), 2.67ꢀ2.87 (m, 2H), 3.47 (t, J
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= 7.2 Hz, 1H), 3.95ꢀ4.07 (m, 2H), 4.90 (s, 1H), 5.07 (s, 1H), 7.21ꢀ7.34 (m, 5H).
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Entry 5: According to the general procedure, the treatment of diol 1h (207.0 mg, 1.498 mmol) with DBDMH
(648.7 mg, 2.269 mmol), BHT (496.0mg, 2.247 mmol) and methoxymethyl phenyl sulfide (330.0 ꢁL, 2.247
mmol), for 15 min afforded 2h (209.7 mg, 93%). Eluent; hexanes→hexanes/Et2O = (50/1).
1-phenylethane-1,2-diol (1h)19
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White solid; 1H NMR (400 MHz, CDCl3) δ: 2.03 (dd, J = 7.3, 4.6 Hz, 1H), 2.49 (d, J = 3.2 Hz, 1H), 3.63ꢀ3.79
(m, 2H), 4.80ꢀ4.84 (m, 1H), 7.27ꢀ7.37 (m, 5H).
4-phenyl-1,3-dioxolane (2h)23
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Yellow oil; H NMR (400 MHz, CDCl3) δ: 3.61 (t, J = 7.6 Hz, 1H), 4.17 (t, J = 7.3 Hz, 1H), 4.91 (t, J = 6.6
Hz, 1H), 5.01 (s, 1H), 5.19 (s, 1H), 7.16ꢀ7.31 (m, 5H).
Entry 6: According to the general procedure, the treatment of diol 1i (95.0 mg, 0.322 mmol) with DBDMH
(189.9 mg, 0.644 mmol), BHT (146.3mg, 0.644 mmol) and methoxymethyl phenyl sulfide (98.0 ꢁL, 0.644
mmol), for 30 min afforded 2i (83.5 mg, 84%). Eluent; hexanes→hexanes/Et2O = (150/1→100/1).
Synthesis of 1i
octadecane-8,9-diol (1i)
Triphenylphosphine (7.6 g, 29 mmol) was added to the solution of 9 (5 mL, 29 mmol) in toluene (29 mL) at
room temperature under N2 and the resulting solution was stirred at 110 ºC. After 9 was consumed (48 h)
(monitored by TLC), the mixture was concentrated in vacuo to afford the crude phosphonium bromide.
NaH (1.2 g, 29 mmol) was added to the solution of the crude phosphonium bromide in THF (63 mL) and
DMSO (10 mL) at 0 ºC under N2 and the mixture was stirred at room temperature for 1 h. Then nꢀdecanal (18
mL, 96 mmol) was added to the reaction mixture at 0 ºC and the solution was stirred at room temperature.
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After the phosphonium salt was consumed (4 h) (monitored by TLC), sat. aqueous NH4Cl was added to the
reaction mixture and the solution was extracted with hexanes (50 mL × 1). The organic layer was dried over
Na2SO4, filtered and concentrated in vacuo. The residue was roughly purified by flash column
chromatography (SiO2, hexanes) affording crude 10.
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A catalytic amount of K2OsO4 was added to the solution of the crude 10 and Nꢀmethylmorpholine ꢀNꢀoxide
(44.6 mmol) in acetone (11 mL) and H2O (3 mL) at room temperature. After 10 was consumed (56 h)
(monitored by TLC), sat. aqueous Na2S2O3 was added to the reaction mixture and the resulting solution was
extracted with AcOEt (30 mL × 3). The combined organic layers were dried over Na2SO4, filtered and
concentrated in vacuo. The residue was subjected to flash column chromatography (SiO2, hexanes/AcOEt =
10/1→AcOEt) affording 1i as yellow solid (2.93 g, 3 steps 41%); m.p. 114 ºC; IR (KBr): 3584, 3154, 2928,
2253, 1790 cmꢀ1; 1H NMR (300 MHz, CDCl3) δ: 0.86 (t, J = 6.5 Hz, 6H), 1.12ꢀ1.46 (m, 28H), 1.67 (brs, 2H),
3.58 (m, 2H), 13C NMR (100 MHz, CDCl3) δ: 14.09, 14.11, 22.6, 22.7, 26.0, 29.2, 29.3, 29.56, 29.58, 29.62,
29.66, 31.2, 31.8, 31.9, 74.7; HRMS (EI) calcd for C18H38O2 (M+) 286.2872, found 286.2862.
4-heptyl-5-nonyl-1,3-dioxolane (2i)
Yellow oil; IR (KBr): 2926, 2253 cmꢀ1; 1H NMR (400 MHz, CDCl3) δ: 0.86 (t, J = 6.8 Hz, 6H), 1.25ꢀ1.56 (m,
28H), 3.87ꢀ3.90 (m, 2H), 4.79 (s, 1H), 5.06 (s, 1H); 13C NMR (100 MHz, CDCl3) δ: 14.1, 22.6, 22.7, 26.4,
29.1, 29.2, 29.3, 29.4, 29.54, 29.56, 29.62, 29.7, 31.8, 31.9, 78.2, 93.7; HRMS (FAB) calcd for C19H38LiO2
(M++Li) 305.3032, found 305.3039.
Entry 7: According to the general procedure, the treatment of diol 1j (65.1 mg, 0.232 mmol) with DBDMH
(132.7 mg, 0.464 mmol), BHT (104.2 mg, 0.472 mmol) and methoxymethyl phenyl sulfide (68.0 ꢁL, 0.464
mmol), for 20 min afforded 2j (51.6 mg, 76%). Eluent; hexanes→hexanes/AcOEt = (10/1).
(6S)-8-(benzyloxy)-2,6-dimethyloctane-2,3-diol (1j)20
Orange oil; 1H NMR (300 MHz, CDCl3) δ: 0.89ꢀ0.92 (m, 3H), 1.14ꢀ1.47 (m, 13H), 2.12 (brs, 2H), 3.29ꢀ3.34
(m, 1H), 3.51ꢀ3.53 (m, 2H), 4.50 (s, 2H), 7.26ꢀ7.35 (m, 5H).
5-[(S)-5-benzyloxy-3-methylpentyl]-4,4-dimethyl-1,3-dioxolane (2j)
Yellow oil; IR (KBr): 3154, 2930, 2253, 1790 cmꢀ1; 1H NMR (400 MHz, CDCl3) δ: 0.84 (d, J = 6.4 Hz, 3H),
1.02ꢀ1.62 (m, 13H), 3.31ꢀ3.36 (m, 1H), 3.39ꢀ3.49 (m, 2H), 4.42 (s, 2H), 4.81 (s, 1H), 4.96 (s, 1H), 7.18ꢀ7.27
(m, 5H); 13C NMR (100 MHz, CDCl3) δ: 19.4, 19.5, 21.20, 21.23, 24.82, 24.85, 26.86, 26.88, 29.9, 30.0, 34.1,
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34.2, 36.5, 36.6, 68.4, 68.5, 72.86, 72.88, 79.3, 84.4, 84.5, 92.6, 127.4, 127.5, 127.6, 128.3, 138.5; HRMS (EI)
calcd for C18H28O3 (M+) 292.2039, found 292.2030.
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Entry 8: According to the general procedure, the treatment of diol 1k (93.2 mg, 0.612 mmol) with DBDMH
(262.5 mg, 0.918 mmol), BHT (202.3mg, 0.918 mmol) and methoxymethyl phenyl sulfide (135.0 ꢁL, 0.918
mmol), for 1 h afforded 2k (85.1 mg, 85%). Eluent; hexanes→hexanes/Et2O = (50/1).
1-phenylpropane-1,3-diol (1k)2a
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White solid; 1H NMR (300 MHz, CDCl3) δ: 1.87ꢀ1.98 (m, 2H), 3.81 (t, J = 5.3 Hz, 2H), 4.91 (dd, J = 8.6, 4.1
Hz, 1H), 7.19ꢀ 7.39 (m, 5H).
4-phenyl-1,3-dioxane (2k)
Colorless oil; 1H NMR (400 MHz, CDCl3) δ: 1.60ꢀ1.66 (m, 1H), 1.97ꢀ2.08 (m, 1H), 3.80 (dt, J =11.8, 2.4 Hz,
1H), 4.12 (dd, J =11.4, 4.6 Hz, 1H), 4.57 (dd, J = 11.2, 2.5 Hz, 1H), 4.81 (d, J = 6.4 Hz, 1H), 5.14 (d, J = 6.4
Hz, 1H), 7.17ꢀ7.31 (m, 5H), Commercially Available.
Entry 9: According to the general procedure, the treatment of diol 1l (64.7 mg, 0.316 mmol) with DBDMH
(137.2 mg, 0.474 mmol), BHT (105.8 mg, 0.474 mmol) and methoxymethyl phenyl sulfide (70.0 ꢁL, 0.474
mmol) for 45 min afforded 2l (40.9 mg, 60%). Eluent; hexanes→hexanes/AcOEt = (5/1→2/1).
undecane-1,2,11-triol (1l)2a
White solid; 1H NMR (500 MHz, CDCl3) δ: 1.27ꢀ1.55 (m, 16H), 1.82 (brs, 1H), 1.97 (brs, 1H), 3.39ꢀ3.45 (m,
1H), 3.59ꢀ3.70 (m, 4H).
9-(1,3-dioxolan-4-yl)nonan-1-ol (2l)2a
Colorless oil;1H NMR (300 MHz, CDCl3) δ: 1.18ꢀ1.59 (m, 16H), 3.34ꢀ3.41 (m, 1H), 3.59 (t, J = 6.5 Hz, 2H),
3.91ꢀ3.96 (m, 2H), 4.82 (s, 1H), 4.97 (s, 1H).
General procedure for methylene acetal formation of sugar-type substrate (Scheme 3)
According to the general procedure, the treatment of diol 5 (50.8 mg, 0.136 mmol) with DBDMH (77.8 mg,
0.272 mmol), BHT (60.0 mg, 0.272 mmol) and methoxymethyl phenyl sulfide (40.0 ꢁL, 0.272 mmol), for 20
min afforded 6 (44.7 mg, 85%). Eluent; hexanes→hexanes/AcOEt = (10/1) .
(2R,3R,4S,5R,6R)-4,5-bis(benzyloxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-ol (5)21
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White solid; H NMR (300 MHz, CDCl3) δ: 1.56 (brs, 1H), 2.23 (brs, 1H), 3.29ꢀ3.53 (m, 4H), 3.56 (s, 3H),
3.70ꢀ3.80 (m, 1H), 3.83ꢀ3.92 (m, 1H), 4.35 (d, J = 7.2 Hz, 1H), 4.67 (t, J = 11.5 Hz, 2H), 4.93 (dd, J = 13.2,
11.2 Hz, 2H), 7.24ꢀ7.36 (m, 10H).
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(4aR,6R,7R,8S,8aR)-7,8-bis(benzyloxy)-6-methoxyhexahydropyrano[3,2-d][1,3]dioxine (6)
Yellow oil; IR (KBr): 2870, 2251, 1709 cmꢀ1; 1H NMR (400 MHz, CDCl3) δ: 3.22ꢀ3.26 (m, 1H), 3.30ꢀ3.35 (m,
2H), 3.43 (t, J = 10.1 Hz, 1H), 3.49 (s, 3H), 3.59 (t, J = 8.9 Hz, 1H), 4.15 (dd, J = 10.5, 5.0 Hz, 1H), 4.32 (d, J
= 7.8 Hz, 1H), 4.55 (d, J = 6.4 Hz, 1H), 4.65 (d, J = 10.8 Hz, 1H), 4.71 (d, J = 11.6 Hz, 1H), 4.78 (d, J = 10.8
Hz, 1H), 4.79 (d, J = 11.6 Hz, 1H), 5.00 (d, J = 6.0 Hz, 1H), 7.18ꢀ7.28 (m, 10H); 13C NMR (100 MHz, CDCl3)
δ: 57.4, 66.1, 68.5, 75.0, 75.2, 80.8, 81.3, 82.1, 93.6, 105.1, 127.6, 127.7, 127.9, 128.0, 128.27, 128.32, 138.3,
138.4; HRMS (EI) calcd for C22H26O6 (M+) 386.1729, found 386.1725.
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Procedure for the synthesis of 6 under acidic conditions.
pꢀToluenesulfonic acid (4.0 mg, 0.02 mmol) was added to the solution of diol 5 (38.6 mg, 0.103 mmol) and
paraformaldehyde (3.4 mg, 0.113 mmol) in toluene (3.4 mL) at room temperature under N2 and the reaction
mixture was stirred at 110 ºC . After 5 was consumed (monitored by TLC), satd. aqueous NaHCO3 (4 mL) was
added to the reaction mixture and the mixture was extracted with AcOEt (30 mL × 3). The combined organic
layers were dried over Na2SO4, filtered and concentrated in vacuo. The residue was subjected to flash column
chromatography (SiO2, hexanes/AcOEt = 5/1) affording 6 (26.6 mg, 67%).
Procedure for the synthesis of 6 under basic conditions.
KOH (48 mg, 0.848 mmol) and dibromomethane (15.0 ꢁL, 0.212 mmol) were added to the solution of diol 5
(39.6 mg, 0.106 mmol) in DMSO (0.22 mL) at room temperature under N2 and the reaction mixture was
stirred at the same temperature for 8 h. Then H2O was added to the reaction mixture and extracted with
CH2Cl2 (30 mL × 3). The combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo.
The residue was subjected to flash column chromatography (SiO2, hexanes/AcOEt = 5/1) affording 6 (15.9 mg,
39%).
Acknowledgement
This work was financially supported by the Hoansha Foundation, the Uehara Memorial Foundation, and
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Grantedꢀinꢀaid for scientific research from the Ministry of Education, Culture, Sports, Sciences, and
Technology of Japan.
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Supporting information
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1H and 13C NMR spectra. This material is available free of charge via the Internet at http://pubs.acs.org/.
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