Synthesis and anti-human immunodeficiency virus type 1 (HIV-1) activity of 3-substituted derivatives of 3'-azido-3'-deoxythymidine (AZT), and inhibition of HIV-1 reverse transcriptase by their 5'-triphosphates

DOI: 10.1248/cpb.40.920

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 920 - 924 (1992)

Update date:2022-09-26

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Authors:

Kitade Kitade

Suzuki Suzuki

Hirota Hirota

Maki Maki

Nakane Nakane

Ono Ono

Baba Baba

Shigeta Shigeta

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Article abstract of DOI:10.1248/cpb.40.920

Various 3-substituted 3'-azido-3'-deoxythymidine analogs (2a-i) were prepared by the reaction of 3'azido-3'-deoxythymidine (1), AZT with N,N-dimethylformamide dialkylacetal or alkyl bromide in the presence of base and their activities against human-immuno

Full text of DOI:10.1248/cpb.40.920

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