Convergent synthesis of the polyene macrolide (-)-roxaticin

Article abstract of DOI:10.1021/ja00084a017

(-)-Roxaticin has been synthesized from polyol tetraacetonide 5, which was prepared by a threefold convergent route. Each of the optically pure building blocks (2, 3, and 4) was prepared using a Noyori asymmetric hydrogenation. Sequential alkylation of di