Journal of the American Chemical Society p. 1753 - 1765 (1994)
Update date:2022-09-26
Topics:
Rychnovsky, Scott D.
Hoye, Rebecca C.
(-)-Roxaticin has been synthesized from polyol tetraacetonide 5, which was prepared by a threefold convergent route. Each of the optically pure building blocks (2, 3, and 4) was prepared using a Noyori asymmetric hydrogenation. Sequential alkylation of di
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