Stereoselective syntheses of the antibiotics (+)-negamycin and (-)-HON (RI-331)

DOI: 10.1055/s-1992-26142

Source and publish data:

Synthesis p. 482 - 486 (1992)

Update date:2022-08-04

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Authors:

Schmidt Schmidt

Stabler Stabler

Lieberknecht

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Article abstract of DOI:10.1055/s-1992-26142

The stereoselective syntheses of the antibiotics (-)-HON (5-hydroxy-4-oxo-L-norvaline, RI-331) and (+)-negamycin starting from (S)-4-[(Z)-2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonyl)vinyl]-2, 2-dimethyl-1,3-dioxolane and (R)-3-benzyloxycarbonyl-5-[(Z)-2-(tert-butoxycarbonylamino)-2-(methoxy carbonyl) vinyl]-2,2-dimethyl-1,3-oxazolidine, respectively, are described.

Full text of DOI:10.1055/s-1992-26142

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