Stereoselective syntheses of the antibiotics (+)-negamycin and (-)-HON (RI-331)

DOI: 10.1055/s-1992-26142

Source and publish data:

Synthesis p. 482 - 486 (1992)

Update date:2022-08-04

Topics:

Authors:

Schmidt Schmidt

Stabler Stabler

Lieberknecht

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1992-26142

The stereoselective syntheses of the antibiotics (-)-HON (5-hydroxy-4-oxo-L-norvaline, RI-331) and (+)-negamycin starting from (S)-4-[(Z)-2-(benzyloxycarbonylamino)-2-(tert-butoxycarbonyl)vinyl]-2, 2-dimethyl-1,3-dioxolane and (R)-3-benzyloxycarbonyl-5-[(Z)-2-(tert-butoxycarbonylamino)-2-(methoxy carbonyl) vinyl]-2,2-dimethyl-1,3-oxazolidine, respectively, are described.

Full text of DOI:10.1055/s-1992-26142

Products guided by the article

Product name:(N-Methyl-hydrazino)-acetic acid benzyl ester; compound with trifluoro-acetic acid

Cas No:142683-68-9

R&D Labs maybe for 142683-68-9

Tomo Pharma Chem Co., Limited

Contact:+86-158-05817090

Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Shandong Xingshun New Material Co., Ltd.

website:http://www.sd-xingshun.com

Contact:+86-519-86461196/+86-519-86464994

Address:Middle of Luhua East Road, Dingtao District
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD

website:http://www.jinjingroup.com

Contact:4009982989

Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD

Contact:29-63685658 63685359

Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China

Relevant to this article

Epimerization of glycal derivatives by a cyclopentadienylruthenium catalyst: Application to metalloenzymatic DYKAT

Doi:10.1002/chem.201403720
(2014)
Synthesis of 2-iminoimidazolidin-4-one derivatives by cyclization of 2-aryl-1-(4,6-dimethylpyrimidin-2-yl)guanidines with ethyl bromoacetate, dimethyl acetylenedicarboxylate, and maleic anhydride

Doi:10.1007/s11172-007-0216-8
(2007)
Synthesis of Polysubstituted Isoquinolines and Related Fused Pyridines from Alkenyl Boronic Esters via a Copper-Catalyzed Azidation/Aza-Wittig Condensation Sequence

Doi:10.1021/acs.joc.7b02831
(2018)
2-[(3a R,4 R,5 S,7a S)-5-{(1 S)-1-[3,5-bis(trifluoromethyl)phenyl]-2- hydroxyethoxy}-4-(2-methylphenyl)octahydro-2 H -isoindol-2-yl]-1,3-oxazol-4(5 H)-one: A potent human NK₁ receptor antagonist with multiple clearance pathways

Doi:10.1021/jm400751p
(2013)
The first synthesis of a novel 5:7:5-fused diimidazodiazepine ring system and some of its chemical properties

Doi:10.1021/ol8020176
(2008)
A new method for the synthesis of 5-amidinobarbiturates

Doi:10.1007/s11172-007-0253-3
(2007)

Article Doi