Synthesis of Chiral Zileuton, A Potent And Selective Inhibitor Of 5-Lipoxygenase

DOI: 10.1016/S0040-4039(00)79043-5

Source and publish data:

Tetrahedron Letters p. 2629 - 2632 (1992)

Update date:2022-08-04

Topics:

Authors:

Hsiao, Chi-Nung

Kolasa, Teodozyj

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Article abstract of DOI:10.1016/S0040-4039(00)79043-5

Coupling and intramolecular Wittig reaction of N-benzyloxy-D-alanine anhydride (13) and (2-Mercaptophenyl)methyltriphenylphosphonium bromide (3) were used as key steps to prepare (+)-enantiomer of zileuton (1), a potent and selective inhibitor of 5-lipoxygenase.

Full text of DOI:10.1016/S0040-4039(00)79043-5

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