Synthesis and functional evaluation of a peptide derivative of 1-β-D- arabinofuranosylcytosine

DOI: 10.1021/jm00096a006

Source and publish data:

Journal of Medicinal Chemistry p. 3344 - 3349 (1992)

Update date:2022-08-04

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Authors:

Balajthy

Aradi Aradi

Kiss Kiss

Elodi Elodi

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Article abstract of DOI:10.1021/jm00096a006

We have synthesized a peptidyl prodrug derivative of 1-β-D- arabinofuranosylcytosine (1) designed to be a selective substrate of plasmin. D-Val-Leu-Lys-ara-C (2) was obtained by coupling the protected peptide Cbz-D- Val-Leu-(N⁶-Cbz)Lys-OH and a

Full text of DOI:10.1021/jm00096a006

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