Studies on organophosphorus compounds 55. A new and facile synthetic route to 1-alkyl(aryl)-2-amino-1-hydroxyalkylphosphonic acids

Article abstract of DOI:10.1055/s-1992-26154

Nucleophilic addition of dimethyl phosphite to acylamino ketones prepared conveniently by the Dakin-West reaction involving reaction of the corresponding α-amino acids and acid anhydrides, followed by subsequent hydrolysis affords 1-alkyl(aryl)-2-amino-1-hydroxyalkylphosphonic acids in satisfactory yield.