Biological active analogues of the opioid peptide biphalin: Mixed α/β3-peptides

DOI: 10.1021/jm301456c

Source and publish data:

Journal of Medicinal Chemistry p. 3419 - 3423 (2013)

Update date:2022-07-30

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Authors:

Mollica, Adriano

Pinnen, Francesco

Costante, Roberto

Locatelli, Marcello

Stefanucci, Azzurra

Pieretti, Stefano

Davis, Peg

Lai, Josephine

Rankin, David

Porreca, Frank

Hruby, Victor J.

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Article abstract of DOI:10.1021/jm301456c

Natural residues of the dimeric opioid peptide Biphalin were replaced by the corresponding homo-β³ amino acids. The derivative 1 containing hβ³ Phe in place of Phe showed good μ- and δ-receptor affinities (K_i^δ =

Full text of DOI:10.1021/jm301456c

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