Asymmetric Alkylation Using Chiral Cyclic Diols to Prepare a Quaternary Carbon

Article abstract of DOI:10.1016/S0040-4020(01)87012-5

Asymmetric alkylation of cyclic and acyclic β-keto ester acetals (4, 5, 13, 14, and 18) with C₂-symmetric cycloalkane-1,2-dioxy moiety proceeded in a highly diastereoselective manner to afford enol ethers (9-12, 15-17, 19a-c) with a chiral quat