A facile and convenient synthetic method for N-β-trifluoroacetylvinyl amino acid esters, α-aminoacetophenones and aminoacetonitriles as potentially useful precursors of fluorine-containing pyrroles

Article abstract of DOI:10.1055/s-1992-26155

N-(4,4,4-Trifluoro-3-oxo-1-butenyl) amino acid esters, α-aminoacetophenones and aminoacetonitriles 3 and 4 are easily obtained in excellent yields by O-N exchange reaction of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones 1 and 2 with some amino acid esters, α-a