Chemo-enzymatic synthesis of bicyclic γ-lactams using clavaminic acid synthase

DOI: 10.1016/S0040-4020(97)00399-2

Source and publish data:

Tetrahedron p. 7011 - 7020 (1997)

Update date:2022-08-04

Topics:

Authors:

Baldwin, Jack E.

Adlington, Robert M.

Bryans, Justin S.

Lloyd, Matthew D.

Sewell, Timothy J.

Schofield, Christopher J.

Baggaley, Keith H.

Cassels, Robert

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Article abstract of DOI:10.1016/S0040-4020(97)00399-2

Incubation of the γ-lactam analogue of proclavaminic acid, (±)-threo-5-amino-3-hydroxy-2-(1'-aza-2'-oxocyclopentyl) acid, led to production of two bicyclic γ-lactam products.

Full text of DOI:10.1016/S0040-4020(97)00399-2

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Product name:benzyl threo-(+/-)-5-benzyloxycarbonylamino-3-hydroxy-2-(1'-aza-2'-oxocyclopentyl)pentanoate

Cas No:143023-97-6

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