New synthetic strategy for the construction of transfused medium-sized cyclic ethers: Synthesis of the IJK framework of the polyether ciguatoxin

Article abstract of DOI:10.1016/S0040-4039(00)92096-3

The synthesis of a conveniently functionalised oxocene-oxane-oxepane framework was achieved by two simultaneous one-carbon homologations followed by a one-pot double carbon-carbon bond-forming strategy.