An alternative and efficient synthesis of 24,24-difluoro-1α,25-dihydroxyvitamin D3

DOI: 10.1248/cpb.40.1120

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1120 - 1124 (1992)

Update date:2022-08-04

Topics:

Authors:

Konno Konno

Ojima Ojima

Hayashi Hayashi

Takayama

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Article abstract of DOI:10.1248/cpb.40.1120

An alternative synthesis of the title compound 2, a highly potent analog of 1α,25-dihydroxyvitamin D₃ (1), is described. Starting with 1α,3β-bis[(tert-butyldimethylsilyl)oxy]androst-5-ene (8), 2 was obtained in 3.8% total yield through 10 steps. This method provides compound 2 in much higher yield than that reported previously.

Full text of DOI:10.1248/cpb.40.1120

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