
Chemical and Pharmaceutical Bulletin p. 1120 - 1124 (1992)
Update date:2022-08-04
Topics:
Konno
Ojima
Hayashi
Takayama
An alternative synthesis of the title compound 2, a highly potent analog of 1α,25-dihydroxyvitamin D3 (1), is described. Starting with 1α,3β-bis[(tert-butyldimethylsilyl)oxy]androst-5-ene (8), 2 was obtained in 3.8% total yield through 10 steps. This method provides compound 2 in much higher yield than that reported previously.
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Doi:10.1021/ol400809n
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