A Facile Synthesis of Disubstituted 1,1-Difluoro-1-alkenes via Double Transmetalation of 2,2-difluorovinylboranes

DOI: 10.1016/0040-4039(92)80023-D

Source and publish data:

Tetrahedron Letters p. 3779 - 3782 (1992)

Update date:2022-08-04

Topics:

Authors:

Ichikawa, Junji

Minami, Toru

Sonoda, Takaaki

Kobayashi, Hiroshi

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Article abstract of DOI:10.1016/0040-4039(92)80023-D

2,2,2-Trifluoroethyl p-toluenesulfonate is treated with butyllithium and trialkylboranes successively to generate 1-alkyl-2,2-difluorovinylboranes, which couple with aryl iodides in the presence of cuprous iodide and palladium catalyst to afford 1,1-difluoro-1-alkenes in excellent yields. Key Words: Difluoroalkene; Difluorovinylborane; Transmetalation; Coupling reaction; Palladium catalyst

Full text of DOI:10.1016/0040-4039(92)80023-D

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