A Facile Synthesis of Disubstituted 1,1-Difluoro-1-alkenes via Double Transmetalation of 2,2-difluorovinylboranes

DOI: 10.1016/0040-4039(92)80023-D

Source and publish data:

Tetrahedron Letters p. 3779 - 3782 (1992)

Update date:2022-08-04

Topics:

Authors:

Ichikawa, Junji

Minami, Toru

Sonoda, Takaaki

Kobayashi, Hiroshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(92)80023-D

2,2,2-Trifluoroethyl p-toluenesulfonate is treated with butyllithium and trialkylboranes successively to generate 1-alkyl-2,2-difluorovinylboranes, which couple with aryl iodides in the presence of cuprous iodide and palladium catalyst to afford 1,1-difluoro-1-alkenes in excellent yields. Key Words: Difluoroalkene; Difluorovinylborane; Transmetalation; Coupling reaction; Palladium catalyst

Full text of DOI:10.1016/0040-4039(92)80023-D

Products guided by the article

Product name:Benzene, [1-(difluoromethylene)-2-methylbutyl]-

Cas No:143264-65-7

R&D Labs maybe for 143264-65-7

Jinan YouCheng Pharmatech Co.,Ltd

Contact:+86-18653163205

Address:No.750, Shunhua Road, University Science Park, High-tech Zone, Jinan City
JIANGSU DINGSHENG CHEMICAL INDUSTRY CO.,LTD

Contact:+86-519-88995252

Address:No.8 Liangshan Rd, Dagang Chemical Industry Park,Zhenjiang NewDistrict ,Jiangsu
Melone Pharmaceutical Co., ltd

Contact:+86-411 82593920, 82593631

Address:No 232, JInma Roda, Development Zone, Dalian, China
Zibo Kunran Enterprises Co. LTD

website:http://www.kunranchem.com

Contact:0086 533 5200669

Address:No. 96 Jinjing Avenue, Zibo, Shandong, China
Shanghai Topchem Co., LTD

website:http://www.shtopchem.com/

Contact:0086-0576-87776998

Address:room no 1608,xuhui business building yude road,xujiahui street, xuhui district

Relevant to this article

Heterogeneous sequential N-arylation of N-heterocycles over copper anchored mesoporous silica catalyst

Doi:10.1016/j.apcata.2015.12.029
(2016)
Anchored [RuCl₂(p-cymene)]₂ in hybrid zirconium phosphate-phosphonate coated and pillared with double-stranded hydrophobic linear polystyrene as heterogeneous catalyst suitable for aqueous asymmetric transfer hydrogenation

Doi:10.1039/c3dt33015j
(2013)
Se-Phenyl Areneselenosulfonates: Their Facile Formation and Striking Chemistry

Doi:10.1021/jo00337a015
(1981)
Synthesis and Transformation of Pyrrole C-Glycoconjugates

Doi:10.1016/0040-4020(92)80012-5
(1992)
6-alkynyl- and 6-aryl-substituted (R)-pipecolic acid derivatives

Doi:10.1021/ol4010728
(2013)
Discovery of Novel 2-Aniline-1,4-naphthoquinones as Potential New Drug Treatment for Leber's Hereditary Optic Neuropathy (LHON)

Doi:10.1021/acs.jmedchem.0c00942
(2020)

Article Doi