Tetrahedron Letters p. 3939 - 3942 (1992)
Update date:2022-08-03
Topics:
Cacchi, Sandro
Lupi, Alessandro
The palladium-catalysed hydroxycarbonylation of vinyl and aryl triflates, under a CO balloon, in the presence of potassium acetate affords α,β-unsaturated and aromatic carboxylic acids with one more carbon in good to high yield.The nature of the solvent and of the ligand have been proved to be crucial for the success of the reaction.Vinyl triflates undergo the hydroxycarbonylation at room temperature in DMF in the presence of Pd(OAc)2(PPh3)2.Aryl triflates produce best results at 60 deg C in DMSO in the presence of Pd(OAc)2 and 1,1-bis(diphenylphosphino)ferrocene (dppf).
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