Ammonium bromides/KF catalyzed trifluoromethylation of carbonyl compounds with (trifluoromethyl)trimethylsilane and its application in the enantioselective trifluoromethylation reaction

Article abstract of DOI:10.1016/j.tet.2007.05.024

The trifluoromethylation of aldehydes and ketones is a potentially powerful method to introduce the CF₃ moiety into organic molecules. In general, the trifluoromethylation reaction has been performed by treatment of Me₃SiCF₃