Highly Stereodivergent Approach to Both Enantiomers of 4-Substituted β-Lactams via Diastereofacially Controlled Addition of Enolates of t-Butyl Acetate to a Chiral Imine

Article abstract of DOI:10.1246/cl.1992.1349

Addition of lithium or triisopropoxytitanium enolate derived from t-butyl acetate to a chiral imine possessing dioxolane ring as a chiral auxiliary gave (3S)-β-amino ester exclusively, whereas chlorozinc enolate underwent re-facial attack to give (3R)-iso