Journal of Medicinal Chemistry p. 3755 - 3773 (1992)
Update date:2022-08-05
Topics:
Weber, Ann E.
Steiner, Mark G.
Krieter, Philip A.
Colletti, Adria E.
Tata, James R.
et al.
Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the
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