Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors

DOI: 10.1021/jm00099a004

Source and publish data:

Journal of Medicinal Chemistry p. 3755 - 3773 (1992)

Update date:2022-08-05

Topics:

Authors:

Weber, Ann E.

Steiner, Mark G.

Krieter, Philip A.

Colletti, Adria E.

Tata, James R.

et al. et al.

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Article abstract of DOI:10.1021/jm00099a004

Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the

Full text of DOI:10.1021/jm00099a004

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