Lewis Acid-Promoted Reaction of β,β-Difluorinated N,O-Acetal with Silylated Nucleophiles

DOI: 10.1246/cl.1992.1377

Source and publish data:

Chemistry Letters p. 1377 - 1380 (1992)

Update date:2022-08-04

Topics:

Authors:

Tsukamoto, Takashi

Kitazume, Tomoya

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Article abstract of DOI:10.1246/cl.1992.1377

Lewis acid-promoted reaction of ethyl 3-ethoxy-2,2-difluoro-3-(dimethylamino)propionate (1) with some silylated nucleophiles afforded β,β-difluoroamines in good yields.The formation of iminium ion intermediate from 1 and BF3*OEt2 was confirmed by 19F and 13C NMR spectroscopy.

Full text of DOI:10.1246/cl.1992.1377

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