Tetrahedron Letters p. 4545 - 4548 (2009)
Update date:2022-08-03
Topics:
Hong, Sam Y.
Nandurdikar, Rahul S.
Keefer, Larry K.
Saavedra, Joseph E.
Chakrapani, Harinath
An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide (NO) prodrug, in an overall yield of 26% in four steps from prolinol is reported; the previously published yield of this transformation was 1%. Using this revised strategy, the
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