Kinetic resolution in asymmetric anti aldol reactions of branched and straight chain racemic 2-phenylsulfanyl aldehydes: Asymmetric synthesis of cyclic ethers and lactones by phenylsulfanyl migration

DOI: 10.1039/p19960001935

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 1935 - 1940 (1996)

Update date:2022-08-05

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Authors:

Chibale, Kelly

Warren, Stuart

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Article abstract of DOI:10.1039/p19960001935

The kinetic resolution of branched and straight chain 2-phenylsulfanyl aldehydes by the Lewis acid-catalysed asymmetric anti aldol reaction followed by reduction to single enantiomers of 1,3-diols and/or acid-catalysed cyclisation with PhS migration provides a route to enantiomerically pure cyclic ethers and lactones with full stereochemical control.

Full text of DOI:10.1039/p19960001935

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