Tetrahedron Letters p. 4609 - 4612 (1992)
Update date:2022-07-29
Topics:
Geen, Graham R.
Kincey, Peter M.
Choudary, Bernadette M.
N-9 alkylated materials are the sole products obtained from extended reaction of 2-aminopurines (potential guanine precursors) with Michael acceptors.This was used as the basis for a highly regioselective synthesis of famciclovir, the oral form of the anti-herpesvirus agent penciclovir. Key Words: Michael addition; 2-aminopurines; regiospecific; famciclovir; penciclovir.
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