Synthesis of Novel MPTP Analogs as Potential Monoamine Oxidase B (MAO-B) Inhibitors

DOI: 10.1021/jm00100a023

Source and publish data:

Journal of Medicinal Chemistry p. 4165 - 4174 (1992)

Update date:2022-08-04

Topics:

Authors:

Kalgutkar, Amit S.

Castagnoli, Neal

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00100a023

The nigrostratial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an excellent substrate and a weak inactivator of the flavoenzyme monoamine oxidase B (MAO-B).In an attempt to develop novel mechanism-based inactivators of MAO-B, we have synth

Full text of DOI:10.1021/jm00100a023

Products guided by the article

Product name:Pyridine, 1-cyclobutyl-1,2,3,6-tetrahydro-4-phenyl-, hydrochloride

Cas No:143887-88-1

R&D Labs maybe for 143887-88-1

Tianjin Ingenochem Technology Co.,Ltd

Contact:+86-22-23677060

Address:Hitech Green Industry Park K2-9-602, Nankai district
Wuhan Hanye Chemical New Material Co.,Ltd

Contact:+86-27-85308141

Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Shandong Loyal Chemical industrial Co.,Ltd

Contact:0533-7451788

Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
Kaymossy BioChem Tech Co., Ltd

website:http://www.kaimosi.com

Contact:0571-87191913/0571-87199097

Address:Room 215, Building 3rd, No.288 Ningxia Road, Qingdao city, China
Beijing Century Richap Chemistry Co.,Ltd

Contact:+86- 010-64455497

Address:Guannan County, Lianyungang City, Jiangsu Province, China

Relevant to this article

Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L

Doi:10.1039/c3md00021d
(2013)
Kinetics anmd Mechanism of Ring Cleavage of 1-Benzyl-4-phenyl-1,2,4-triazolium Chloride

Doi:10.1002/prac.19923340306
(1992)
A practical method for regiocontrolled one-carbon ring contraction

Doi:10.1016/j.tet.2013.04.027
(2013)
Ultrasound-promoted Carbonyl Allylation by Allylic Alcohols with Palladium-Tin Dichloride in Nonpolar Solvents: Inversed Regiocontrol of Carbonyl Allylation in Polar Solvents

Doi:10.1039/c39920001102
(1992)
Antimicrobial and antiquorum-sensing studies. Part 2: Synthesis, antimicrobial, antiquorum-sensing and cytotoxic activities of new series of fused [1,3,4]thiadiazole and [1,3]benzothiazole derivatives

Doi:10.1007/s00044-013-0637-x
(2014)
Stereoselective carbon-carbon bond formation: γ-Alkylation of lithium dianion of chiral cyclic β-enamino ketones

Doi:10.1016/S0957-4166(00)80510-8
(1992)

Article Doi