Synthesis of Novel MPTP Analogs as Potential Monoamine Oxidase B (MAO-B) Inhibitors

DOI: 10.1021/jm00100a023

Source and publish data:

Journal of Medicinal Chemistry p. 4165 - 4174 (1992)

Update date:2022-08-04

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Authors:

Kalgutkar, Amit S.

Castagnoli, Neal

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Article abstract of DOI:10.1021/jm00100a023

The nigrostratial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is an excellent substrate and a weak inactivator of the flavoenzyme monoamine oxidase B (MAO-B).In an attempt to develop novel mechanism-based inactivators of MAO-B, we have synth

Full text of DOI:10.1021/jm00100a023

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