The First Mechanism-Based Inactivators for Angiotensin-Converting Enzyme

DOI: 10.1021/jm00100a024

Source and publish data:

Journal of Medicinal Chemistry p. 4175 - 4179 (1992)

Update date:2022-08-04

Topics:

Authors:

Ghosh, Soumitra S.

Said-Nejad, Odile

Roestamadji, Juliatiek

Mobashery, Shahriar

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Article abstract of DOI:10.1021/jm00100a024

The first example of mechanism-based inactivation of angiotensin-converting enzyme (ACE) is described for N--L-phenylalanine (compound 1).It is proposed that an ACE-mediated deprotonation of 1 unmasks a ketenimine intermedi

Full text of DOI:10.1021/jm00100a024

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