The Synthesis of N-Substituted Ureas II: Nucleophilic Substitution of Ureas at the Carbonyl Group

Article abstract of DOI:10.1007/BF00816856

N-Arylsubstituted ureas undergo exchange of the N'-residue upon reaction with amines.Using kinetic measurements, investigation of product distribution, regioselectivity, catalysis, and substrate influences, it was shown that this reaction proceeds via a s