A pentacoordinate boron-containing π-electron system with Cl-B-Cl three-center four-electron bonds

Article abstract of DOI:10.1021/ja404724f

Tricoordinate boron-containing π-electron systems are an attractive class of compounds with intense fluorescence and strong electron-accepting properties. However, the impact of pentacoordination of the boron atoms on their properties has not been determined. We now disclose a B,B′-bis(1,8- dichloro-9-anthryl)-substituted 9,10-dihydro-9,10-diboraanthracene as a new pentacoordinate organoboron compound. In this skeleton, with the aid of the orthogonal arrangement of the anthryl substituent, the B and Cl atoms can form a three-center four-electron (3c-4e) Cl-B-Cl bond. The pentacoordination of the boron atom significantly perturbs the electronic structure and thereby the photophysical and electrochemical properties.

Full text of DOI:10.1021/ja404724f

Communication
pubs.acs.org/JACS
A Pentacoordinate Boron-Containing π‑Electron System with Cl−B−
Cl Three-Center Four-Electron Bonds
Chuandong Dou, Shohei Saito, and Shigehiro Yamaguchi*
Institute of Transformative Bio-Molecules (WPI-ITbM), Department of Chemistry, Graduate School of Science, Nagoya University,
Furo, Chikusa, Nagoya 464-8602, Japan
S
* Supporting Information
Chart 1. Pentacoordinate Organoboron Compounds 1−3 and
Dianthryl-Substituted Dihydrodiboraanthracenes 4
ABSTRACT: Tricoordinate boron-containing π-electron
systems are an attractive class of compounds with intense
fluorescence and strong electron-accepting properties.
However, the impact of pentacoordination of the boron
atoms on their properties has not been determined. We
now disclose a B,B′-bis(1,8-dichloro-9-anthryl)-substituted
9,10-dihydro-9,10-diboraanthracene as a new pentacoordi-
nate organoboron compound. In this skeleton, with the aid
of the orthogonal arrangement of the anthryl substituent,
the B and Cl atoms can form a three-center four-electron
(3c−4e) Cl−B−Cl bond. The pentacoordination of the
boron atom significantly perturbs the electronic structure
and thereby the photophysical and electrochemical
properties.
positions (1.40 Å). Besides these examples, a pentacoordinate
boron compound with a N−B−N bond was also recently
reported.6
uch attention has been paid to organic compounds
Mpossessing extracoordination from both theoretical and
experimental points of view.1 For example, pentacoordinate
carbon compounds with trigonal-bipyramidal (TBP) structures
have been investigated as models of the transition state in the SN2
reaction.2 Higher-coordinate silicon compounds have drawn
continuous attention because of their characteristic reactivity and
properties,3 as exemplified by the recent success in the synthesis
of pentacoordinate disilanes.4 Extracoordination of other
elements such as phosphorus, sulfur, and iodine has also been
the subject of extensive research.5 In contrast, organoboron
compounds with pentacoordination are still limited to only a few
examples, as the second-row boron atom with its small size
preferentially forms tetracoordinate species upon interaction
with inter- or intramolecular coordinating groups.6
In 1984, Martin’s group succeeded in the synthesis of 1 as the
first example of a pentacoordinate organoboron compound.7
The vacant p orbital of its boron atom interacts with two sets of
alkoxylate lone-pair electrons at the axial positions of the TBP
geometry. This axial interaction forms a three-center four-
electron (3c−4e) bond. Later, compounds 2 and 3 were
synthesized by the Akiba and Yamamoto groups as a new family
of pentacoordinate boranes (Chart 1).8 Accurate X-ray electron
density distribution analysis as well as detailed theoretical
calculations revealed the character of their 3c−4e bonds.
Notably, these examples employed oxygen atoms at the axial
positions.8 In particular, 2 has an anthryl group that forces the
two methoxy groups at the 1- and 8-positions to coordinate to
the boron center. The B···O distances are 2.38−2.44 Å, which is
∼1.7 times the length of the B−Ocatechol bonds at the equatorial
We now disclose the new pentacoordinate borane 4Cl. This
compound consists of a planar dihydrodiboraanthracene π
skeleton with a 1,8-dichloro-9-anthryl substituent on each B
atom. The attractive electronic and photophysical properties of
diboraanthracene π-electron systems with tri- or tetracoordinate
boron atoms have been intensively investigated.9 In compound
4Cl, the orthogonal arrangement of each anthryl group forces the
two chlorine atoms to be located in close proximity to the boron
atom at the TBP axial positions. This compound provides us a
suitable molecular scaffold to study (1) the intrinsic character of
the Cl···B···Cl axial interaction and (2) the impact of the
Cl···B···Cl interaction on the electronic structure of the boron-
containing π-electron system. Tri- and tetracoordinate boron-
containing π-systems have been proven to have high potential for
use in various applications, such as emissive organic solid
materials, electron-transporting materials, and chemosensors for
anions.10 However, the impact of pentacoordination of the boron
atoms on their electronic properties has not yet been
determined.8d
Compound 4Cl was unexpectedly obtained from orthogonally
twisted dianthryl-substituted 9,10-dihydro-9,10-diboraanthra-
cene 5. Compounds similar to 5 were recently reported by
Wagner and co-workers.9c The difference between 5 and those
other compounds is that 5 has mesityloxy (OMes) groups at the
4- and 5-positions of the anthryl groups. Our intention was to
Received: May 11, 2013
© XXXX American Chemical Society
A
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Journal of the American Chemical Society
Communication
conduct oxidative annulation of 5 to synthesize a boron-doped
teranthene skeleton, and we envisioned that the electron-
donating OMes groups would facilitate the annulation
reaction.11 Indeed, using this approach we recently synthesized
a boron-doped nanographene-type compound from a dibor-
apentacene precursor, 6 [see the Supporting Information
(SI)].12
Compound 5 was treated with an excess amount of FeCl3
(15.5 equiv) in a CH3NO2/CH2Cl2 mixed solvent (Scheme 1).
Scheme 1. Synthesis of Pentacoordinate
Dihydrodiboraanthracene 4Cl
However, instead of the annulation, the unexpected fourfold
chlorination proceeded at the 1- and 8-positions of both of the
anthryl groups to give 4Cl in 31% yield. Although chlorination
sometimes takes place as a side reaction when FeCl3 is employed
as an oxidant,13 the rather high yield of the tetrachlorinated
product was unexpected and is likely due to an enhancement of
the reactivity at the 1- and 8-positions by the OMes groups. In
addition, this result is in contrast to the fact that 6 smoothly
underwent the annulation reaction. This difference may be due
to the significant passivation of the diborylated benzene rings in 5
toward the electrophilic substitution reaction.
Notably, the product 4Cl was stable enough to handle with
water and isolate by silica gel column chromatography without
any precautions. Although the precursor 5 could be also purified
by silica gel column chromatography, a subtle degradation was
observed under the high-dilution conditions (10−5 M) during the
photophysical measurements (see the SI). A similar observation
was also reported by Wagner’s group.9c In contrast, we did not
observe any spectral change in 4Cl even under high-dilution
conditions during repeated photophysical measurements.
A single crystal of 4Cl suitable for X-ray crystallographic
analysis was obtained by the vapor diffusion of MeOH into a
CHCl3 solution of the compound.14 The structural analysis
confirmed that the geometry of 4Cl has Ci symmetry and has an
orthogonally twisted conformation in which the terminal anthryl
groups and the central diboraanthracene skeleton form the
dihedral angles of 87.1° (Figure 1a). Both of the B atoms take a
TBP geometry with the sum of the equatorial C−B−C angles
equal to 360.0°. More importantly, the B atoms are sandwiched
by two Cl atoms in close proximity. The B···Cl distances are
2.707(4) and 2.727(4) Å, which are much shorter than the sum
of the B and Cl van der Waals radii (3.67 Å)15 but still ∼1.5 times
longer than ordinary B−Cl covalent bonds (1.84 Å). The anthryl
C−B bond length of 1.609(5) Å in 4Cl is also elongated
compared to those in 5 [1.560(4) and 1.581(4) Å]. This may
result from the interaction between the B atom and the two Cl
atoms.
Figure 1. (a) Crystal structure of 4Cl (50% probability for the thermal
ellipsoids). (b) Atoms-in-molecules (AIM) analysis of 4Cl, showing B
(blue), Cl (green), C (black), and H (white) atoms as well as the bond
paths (pink wires) and bond critical points (red dots). The peripheral
groups have been omitted for clarity.
levels of theory, including B3PW91/6-311+G(2d,p), B3LYP/6-
311+G(2d,p), and M06HF/6-311+G(2d,p) (see the SI), among
which the B3PW91 calculation reproduced well the structural
parameters observed in the crystal structure.16 In the optimized
structure with Ci symmetry, the two B···Cl distances become
identical to each other at 2.727 Å, which is comparable to the
experimental distances. The calculated Cl···B···Cl angle is 173.1°.
Atoms-in-molecules (AIM) analysis of the optimized structure
demonstrated that there are bond paths between each central B
atom and its two Cl atoms, indicative of their attractive
interaction (Figure 1b).17 The values of the electron density
(ρ) and its Laplacian (∇2ρ) at the bond critical points (BCPs)
were computed to be 0.020 e/a03 (where a0 is the Bohr radius)
5
and 0.048 e/a0 , respectively. These values are comparable to
those for the reported pentacoordinate organoboron com-
pounds8 and indicate the weak and ionic character of the B···Cl
interaction. In addition, careful inspection of the molecular
orbitals (MOs) showed that 4Cl has bonding, nonbonding, and
antibonding MOs typical for the 3c−4e bond (HOMO−31,
HOMO−28, and LUMO+2, respectively; Figure 2). All of these
results led to the conclusion that the two B atoms in 4Cl have
pentacoordinate character.
NMR spectroscopy provided insight into the structure of 4Cl
in solution. The 11B NMR spectrum of 4Cl in CDCl3 showed a
broad signal at 49 ppm, which was shifted slightly upfield from
that of 5 (60 ppm) (see the SI). This trend is consistent with
those for the reported pentacoordinate boron compounds8 and
implies that 4Cl has a pentacoordinate structure even in solution.
The shielding effect of the pentacoordination was also supported
by the theoretical NMR calculations at the B3PW91/6-
311+G(2d,p) level. The calculated chemical shift of the 11B
atom in 4Cl was upfield shifted by 16 ppm relative to that in 5
(see the SI).
To elucidate the intrinsic character of the B···Cl interaction in
4Cl, we conducted quantum-chemical calculations. Our
particular interest was whether the B···Cl contacts result from
attractive 3c−4e Cl−B−Cl bonding or simply from steric
enforcement due to the spatial proximity.8 We performed full
geometry optimizations with tight convergence criteria at several
B
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Journal of the American Chemical Society
Communication
To elucidate the significant difference in the photophysical
properties of 4Cl and 5, we compared their electronic structures
(Figure 4). Density functional theory (DFT) calculations at the
Figure 2. (a) Antibonding, (b) nonbonding, and (c) bonding MOs for
the 3c−4e Cl−B−Cl bonds in 4Cl. The DFT calculation was performed
at the B3PW91/6-311+G(2d,p) level.
Figure 4. Kohn−Sham MOs of 4Cl and 5 calculated at the B3PW91/6-
311+G(2d,p) level.
Importantly, the pentacoordination of the central B atoms via
axial coordination of the Cl atoms had a significant impact on the
photophysical properties of the π system. While a solution of
tricoordinate 5 in common organic solvents showed a pink color,
a solution of the pentacoordinate 4Cl was yellow. The absorption
spectrum of 5 in toluene (Figure 3) showed a characteristic
B3PW91/6-311+G(2d,p) level demonstrated that the dichlori-
nation of both anthryl groups decreased the energy levels of the π
and π* orbitals localized on the anthryl moieties by ∼0.1 and
∼0.3 eV, respectively. These shifts are due to the inductive effect
of the electron-withdrawing Cl atoms. In contrast, the LUMO of
5, which reflects the p−π* conjugation in the dihydrodiboraan-
thracene skeleton, is significantly elevated in energy and becomes
the LUMO+2 in 4Cl as a result of the antibonding interaction
with the orbitals of the two Cl atoms. The extent of the shift
amounts to 1 eV. This is the impact of the pentacoordination on
the electronic structure. As a result, the pentacoordinate 4Cl has
a slightly lower HOMO level and a much higher LUMO level
compared with 5. On the basis of time-dependent DFT
abs
max
calculations, the broad absorption band observed for 5 (λ
=
522 nm) is assigned to the intramolecular charge transfer (ICT)
transition from the electron-donating anthryl moieties to the
dihydrodiboraanthracene moiety (see the SI). This assignment
was already discussed in the reported 9,10-dianthryl-9,10-
diboraanthracene systems.9c,d In contrast, the structured
absorption band observed for 4Cl is the π−π* transition
centered on the terminal anthracene moieties.
Consistent with the calculation results, the pentacoordination
significantly perturbs the electrochemical properties as well. In
cyclic voltammetry (see the SI), 5 showed two-step reversible
redox processes with first and second reduction potentials of E1/2
= −1.68 and −2.48 V vs Fc/Fc+ in THF and a quasi-reversible
redox wave with the first oxidation potential of E1/2 = +0.61 V vs
Fc/Fc+ in CH2Cl2.9c,d In contrast, the pentacoordinate 4Cl
showed two-step reversible redox waves with more positive
oxidation potentials of E1/2 = +0.70 and +0.79 V vs Fc/Fc+ (as
confirmed by differential pulse voltammetry measurements) and
irreversible reduction processes with much more negative
cathodic peak potentials (Epc = −2.23, −2.43, and −2.64 V vs
Fc/Fc+) than 5.
Figure 3. UV/vis absorption (black) and fluorescence (red) spectra for
(a) 4Cl and (b) 5 in toluene. The insets show photographs of 4Cl and 5
in toluene.
abs
broad, weak band at λ = 522 nm in addition to an intense band
max
abs
max
at λ
= 409 nm with vibronic structure. In contrast, the
absorption spectrum of 4Cl showed only a structured absorption
abs
band with a longest λ of 432 nm. In the fluorescence spectra,
max
em
max
while 5 showed a broad band at λ = 632 nm with a low
quantum yield of Φ = 0.06, 4Cl showed blue fluorescence at λ
em
max
= 447 nm (ΦF = 0.03). While the fluorescence spectrum of 5
showed a large solvent effect (solvent, λemmax/nm: toluene, 632;
THF, 693; CHCl3, 698; CH2Cl2, 743), the emission band of 4Cl
was less sensitive to the solvent polarity (toluene, 467; THF, 467;
CHCl3, 473), except for CH2Cl2 (512 nm).18
Finally, to clarify the features of the 3c−4e Cl−B−Cl bond
compared with other X−B−X interactions, we conducted DFT
calculations on the model compounds 4F and 4OMe (Chart 1),
which have F and MeO substitutents, respectively, in place of the
C
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Journal of the American Chemical Society
Communication
Cl atoms (see the SI). Similar to 4Cl, their optimized structures
have the anthryl moieties arranged orthogonally to the
dihydrodiboraanthracene skeleton with dihedral angles of
90.0°. In 4F, the B···F distance (2.51 Å) is shorter than the
sum of the van der Waals radii of the B and F atoms (3.39 Å).
Nevertheless, the AIM analysis of 4F did not show any bond path
between the B and F atoms. The absence of an attractive B···F
interaction is likely due to the small size and weak donating
ability of the F atom. In contrast, the AIM analysis of 4OMe
showed a bond path between the B and O atoms with ρ = 0.021
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S
* Supporting Information
Experimental procedures, crystallographic data (CIF) for 4Cl
and 5, photophysical properties, theoretical calculations, and
complete ref 16 (as ref S4). This material is available free of
charge via the Internet at http://pubs.acs.org. The supplemen-
tary crystallographic data for 4Cl (CCDC-924601) and 5
(CCDC-924602) have also been deposited with the Cambridge
Crystallographic Data Centre.
AUTHOR INFORMATION
■
Corresponding Author
yamaguchi@chem.nagoya-u.ac.jp
(18) The origin for the irregular red shift in CH2Cl2 is unclear at this
stage.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
This work was partially supported by a Grant-in-Aid for Scientific
Research on Innovative Areas (Stimuli-Responsive Chemical
Species, 24109007) from the Ministry of Education, Culture,
Sports, Science, and Technology of Japan, JST CREST, and JST
PRESTO.
D
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