A novel orally active inhibitor of IL-1 generation: Synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives

DOI: 10.1021/jm00103a003

Source and publish data:

Journal of Medicinal Chemistry p. 4665 - 4675 (1992)

Update date:2022-07-30

Topics:

Authors:

Tanaka Tanaka

Chiba Chiba

Okita Okita

Kaneko Kaneko

Tagami Tagami

Hibi Hibi

Okamoto Okamoto

Shirota Shirota

Goto Goto

Obaishi Obaishi

Sakurai Sakurai

Machida Machida

Yamatsu Yamatsu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00103a003

A new series of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acids was prepared and the inhibitory activities of its members on IL-1 generation were evaluated both by in vitro systems using human monocytes and/or rat exudated macrophages stimulated with LPS,

Full text of DOI:10.1021/jm00103a003

Products guided by the article

Product name:1-Naphthalenol, 7-ethyl-2-methoxy-

Cas No:144272-90-2

R&D Labs maybe for 144272-90-2

SHIJIAZHUANG HENRYTE CHEMICALS CO,.LTD(expird)

Contact:+86-311-85208698 311-80837698

Address:NO.166, yuhua west road, SHIJIAZHUANG, China
guide(suzhou) fine materials co. ltd

Contact:0512-80972173

Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Anhui Xinyuan Technology Co.,Ltd

Contact:0086-559-3515800

Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
Nanjing Capatue Chemical Co., Ltd

Contact:+86-25-86371192 +86-025-85720158

Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
Shandong Xiangde Biotechnology Co., Ltd

Contact:+86 -15066639877

Address:Sanba street

Relevant to this article

Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid

Doi:10.3762/bjoc.10.220
(2014)
Synthesis and characterization of some novel glycodendrimers and N-alkyldendrimers with amide core and triazole functionality through click chemistry

Doi:10.1080/00397911.2012.696304
(2013)
A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis

Doi:10.1016/j.bmc.2014.10.042
(2014)
Synthesis and Biological Activity of 3-<2-(Dimethylamino)ethyl>-5-<(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)methyl>-1H-indole and Analogues: Agonists for the 5-HT_1D Receptor

Doi:10.1021/jm00045a006
(1994)
Novel Triazenes and Triazolines from the Base-Catalyzed Hydrolysis of 1,3-Dialkyl-3-acyltriazenes

Doi:10.1021/jo00050a016
(1992)
Carborane-β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Doi:10.1039/c4tb01489h
(2015)

Article Doi