A novel orally active inhibitor of IL-1 generation: Synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives

DOI: 10.1021/jm00103a003

Source and publish data:

Journal of Medicinal Chemistry p. 4665 - 4675 (1992)

Update date:2022-07-30

Topics:

Authors:

Tanaka Tanaka

Chiba Chiba

Okita Okita

Kaneko Kaneko

Tagami Tagami

Hibi Hibi

Okamoto Okamoto

Shirota Shirota

Goto Goto

Obaishi Obaishi

Sakurai Sakurai

Machida Machida

Yamatsu Yamatsu

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Article abstract of DOI:10.1021/jm00103a003

A new series of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acids was prepared and the inhibitory activities of its members on IL-1 generation were evaluated both by in vitro systems using human monocytes and/or rat exudated macrophages stimulated with LPS,

Full text of DOI:10.1021/jm00103a003

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