A novel orally active inhibitor of IL-1 generation: Synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives

DOI: 10.1021/jm00103a003

Source and publish data:

Journal of Medicinal Chemistry p. 4665 - 4675 (1992)

Update date:2022-07-30

Topics:

Authors:

Tanaka Tanaka

Chiba Chiba

Okita Okita

Kaneko Kaneko

Tagami Tagami

Hibi Hibi

Okamoto Okamoto

Shirota Shirota

Goto Goto

Obaishi Obaishi

Sakurai Sakurai

Machida Machida

Yamatsu Yamatsu

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00103a003

A new series of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acids was prepared and the inhibitory activities of its members on IL-1 generation were evaluated both by in vitro systems using human monocytes and/or rat exudated macrophages stimulated with LPS,

Full text of DOI:10.1021/jm00103a003

Products guided by the article

Product name:1-Naphthalenol, 7-ethyl-2-methoxy-

Cas No:144272-90-2

R&D Labs maybe for 144272-90-2

Shanghai chemrole co.,ltd

Contact:021-50278900

Address:No.6,Room 201 ,Lane 299,bisheng road ,shanghai ,china
Suzhou Ryan Pharmachem Technology Co.,Ltd

Contact:+86-0512-68780025

Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Weinan Rigel Pharm Co., Ltd.

Contact:+86-913-2223392

Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)

Contact:22-58516360

Address:tianjin
Taixing Shenfeng Chemical Co., Ltd.

Contact:+86-523-87117033, 87117666

Address:4# Yinsanlu, Huangqiao town, Taixing, Jiangsu, China.

Relevant to this article

Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid

Doi:10.3762/bjoc.10.220
(2014)
Synthesis and characterization of some novel glycodendrimers and N-alkyldendrimers with amide core and triazole functionality through click chemistry

Doi:10.1080/00397911.2012.696304
(2013)
A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis

Doi:10.1016/j.bmc.2014.10.042
(2014)
Synthesis and Biological Activity of 3-<2-(Dimethylamino)ethyl>-5-<(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)methyl>-1H-indole and Analogues: Agonists for the 5-HT_1D Receptor

Doi:10.1021/jm00045a006
(1994)
Novel Triazenes and Triazolines from the Base-Catalyzed Hydrolysis of 1,3-Dialkyl-3-acyltriazenes

Doi:10.1021/jo00050a016
(1992)
Carborane-β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Doi:10.1039/c4tb01489h
(2015)

Article Doi