Ce(OTf)3-catalyzed multicomponent domino cyclization- aromatization of ferrocenylacetylene, aldehydes, and amines: A straightforward synthesis of ferrocene-containing quinolines

Article abstract of DOI:10.1016/j.tet.2013.05.026

A straightforward and economic method for the synthesis of ferrocene-containing quinolines by the Ce(OTf)₃-catalyed one-pot three-component domino cyclization/aromatization reaction of ferrocenylacetylene, aldehydes, and amines under an air atmosphere was developed. A series of ferrocene substituted quinolines have been synthesized from simple and readily available starting materials in good yields.