ATP-citrate lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-β-lactam containing analogues of citric acid as potential tight-binding inhibitors

Article abstract of DOI:10.1021/jm00104a014

Citric acid analogues (±)-12a,b and (±)-17a,b, where one of the primary carboxylates has been replaced by a sulfoximinoyl and a 3-(3-hydroxy-β- lactamyl) moiety, respectively, have been synthesized and evaluated as inhibitors of ATP-citrate lyase. The des