Synthesis of 2-alkyl-2-arylcyanoacetates via CuI/sodium picolinate-catalyzed direct arylation of α-substituted cyanoacetates

Article abstract of DOI:10.1016/j.tetlet.2013.05.057

CuI/sodium picolinate-catalyzed direct arylation of α-substituted cyanoacetates takes place at 60 C in the presence of Cs₂CO ₃ and 4 A? molecular sieve, affording 2-alkyl-2- arylcyanoacetates in good to excellent yields. Both electro