Bioorganic and Medicinal Chemistry p. 4225 - 4232 (2013)
Update date:2022-07-30
Topics:
Carrau, Gonzalo
Drewes, Carine C.
Shimada, Ana Lúcia B.
Bertucci, Ana
Farsky, Sandra H.P.
Stefani, Helio A.
Gonzalez, David
A small library of compounds was prepared by a combination of toluene dioxygenase (TDO)-catalyzed enzymatic dihydroxylation and copper(I)-catalyzed Hüisgen cycloaddition. Some compounds were obtained by coupling an alkyne and a conduritol derivative, while more complex structures were obtained by a double Hüisgen reaction of a dialkyne and two molecules of the cyclitol. The compounds were fully characterized and subjected to preliminary biological screening.
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(2016)
