Synthesis of Carbocyclic Analogues of Guanosine 5'-(β-L-Fucopyranosyl diphosphate) (GDP-Fucose) as Potential Inhibitors of Fucosyltransferases

DOI: 10.1021/jo00051a004

Source and publish data:

Journal of Organic Chemistry p. 6693 - 6696 (1992)

Update date:2022-07-31

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Authors:

Cai, Shaopei

Stroud, Mark R.

Hakomori, Senitiroh

Toyokuni, Tatsushi

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Article abstract of DOI:10.1021/jo00051a004

Two carbocyclic analogues of GDP-fucose consisting of 5a-carba-β-L-fucopyranose and its unsaturated counterpart have been synthesized as potential inhibitors of fucosyltransferases through the intramolecular Emmons-Horner-Wadsworth olefination of the 2,6-

Full text of DOI:10.1021/jo00051a004

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