Tetrahedron p. 2389 - 2400 (1991)
Update date:2022-08-04
Topics: Chemical Structure Suppression Method Orthogonality Ribosome Binding tRNA-Aminoacyl tRNA Synthetase Pair Competition with Endogenous Amino Acids Codon Choice
Bain
Wacker, Dean A.
Kuo, Eric E.
Chamberlin, A. Richard
A systematic survey of the structural requirements for biosynthetic incorporation of non-natural residues into a polypeptide is presented. Relative translation efficiencies for a series of 12 semi-synthetic acylated suppressor tRNAs ranged from 0 to 91% depending on the structure of the residue incorporated.
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