Highly Diastereoselective Hydrocyanation of β-Keto Sulfoxides: Synthesis of Enantiomerically Pure Cyanohydrin Derivatives

DOI: 10.1021/jo00052a044

Source and publish data:

Journal of Organic Chemistry p. 7235 - 7241 (1992)

Update date:2022-08-04

Topics: Enantiomerically pure Diastereoselective Hydrocyanation β-Keto Sulfoxides

Authors:

Ruano, Jose L. Garcia

Castro, Ana M. Martin

Rodriguez, Jesus H.

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Article abstract of DOI:10.1021/jo00052a044

The reactions of chiral β-keto sulfoxides, R¹-CO-CHR²-SOTol (R¹ = Me, n-Pr, i-Pr, t-Bu, Ph; R² = H, Me) with Et2AlCN yield the corresponding sulfinyl cyanohydrins with high yields (85-96percent) and de (>96perce

Full text of DOI:10.1021/jo00052a044

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