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Dynamic kinetic resolution of β′-keto-β-amino esters using Ru-DTBM-Sunphos catalyzed asymmetric hydrogenation

DOI: 10.1016/j.tet.2013.05.136

Source and publish data:

Tetrahedron p. 7152 - 7156 (2013)

Update date:2022-08-02

Topics: NMR spectroscopy   Catalyst   Hydrogenation   Enantioselectivity   Enantiomeric excess (ee)   Chiral Stationary Phase (CSP)   Asymmetric Hydrogenation   Dynamic Kinetic Resolution (DKR)   Reaction Monitoring   Substrate   HPLC Analysis   Chiral Auxiliary   Racemization   Reaction Optimization   Chiral Ligand   Stereocenter   Turnover frequency (TOF)  

Authors:

Li, XiaomingLi, Xiaoming

Tao, XiaomingTao, Xiaoming

Ma, XinMa, Xin

Li, WanfangLi, Wanfang

Zhao, MengmengZhao, Mengmeng

Xie, XiaominXie, Xiaomin

Ayad, TaharAyad, Tahar

Ratovelomanana-Vidal, VirginieRatovelomanana-Vidal, Virginie

Zhang, ZhaoguoZhang, Zhaoguo

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Article abstract of DOI:10.1016/j.tet.2013.05.136

A convenient method for the enantioselective synthesis of β′-hydroxy-β-amino esters was developed through intensive investigations of the reaction conditions. Dichloromethane (DCM)/2,2,2- trifluoroethanol (TFE) and 1,2-dichloroethane (DCE)/TFE combination

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Full text of DOI:10.1016/j.tet.2013.05.136

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