Accelerating influence of the gem-difluoromethylene group in a ring-closing olefin metathesis reaction. A Thorpe-Ingold effect?

DOI: 10.1039/c3cc44312d

Source and publish data:

Chemical Communications p. 7201 - 7203 (2013)

Update date:2022-07-30

Topics:

Authors:

Urbina-Blanco, Cesar A.

Skibinski, Maciej

O'Hagan, David

Nolan, Steven P.

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Article abstract of DOI:10.1039/c3cc44312d

The gem-difluoromethylene (CF₂) group significantly accelerates ring-closing metathesis of 1,8-nonadienes relative to the methylene (CH ₂) group demonstrating similar rate accelerations to that observed for the classic Thorpe-Ingold substituents, diester malonates and ketals.

Full text of DOI:10.1039/c3cc44312d

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