The stereoselective addition of organometallic reagents to electron-deficient alkylidenecyclohexanes; alternative linkages for cholaphane synthesis

DOI: 10.1016/S0040-4020(01)89447-3

Source and publish data:

Tetrahedron p. 8725 - 8738 (1992)

Update date:2022-08-05

Topics:

Authors:

Davis, Anthony P.

Egan, Thomas J.

Orchard, Michael G.

Cunningham, Desmond

McArdle, Patrick

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Article abstract of DOI:10.1016/S0040-4020(01)89447-3

Knoevenagel condensations between t-butylcyclohexanone and malononitrile, Meldrum's acid and ethyl cyanoacetate gave electron-deficient alkenes which underwent equatorial-selective attack by chemoselective aryl organometallic reagents. Further transformat

Full text of DOI:10.1016/S0040-4020(01)89447-3

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Product name:isopropylidene (4-t-butylcyclohexylidene)malonate

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