Asymmetric Cycloadditions of Aldehydes to Stabilised Azomethine Ylids: Enantiocontrolled Construction of β-Hydroxy-α-amino acid Derivatives

Article abstract of DOI:10.1016/S0957-4166(00)82093-5

In the absence of added dipolarophile, chiral stabilised azomethine ylids derived from the reaction of 5-(S)-phenylmorpholin-2-one (1) with aldehydes undergo efficient and highly enantiocontrolled cycloaddition with a second molecule of aldehyde to furnis