SYNTHESIS OF α-AMINONITRILES BY SELF-CATALYZED, STOICHIOMETRIC REACTION OF PRIMARY AMINES, ALDEHYDES, AND TRIMETHYLSILYL CYANIDE

Article abstract of DOI:10.1016/S0040-4039(00)60956-5

α-Aminonitriles can be prepared at room temperature in good yield by either the addition of a primary amine to a mixture aldehyde/trimethylsilyl cyanide (TMSCN) or by the addition of an aldehyde to a mixture amine/TMSCN.The reaction proceeds via the initi