Toward the Synthesis of the Taxol C,D Ring System: Photolysis of α-Methoxy Ketones

Article abstract of DOI:10.1016/S0040-4020(01)91212-8

Model systems for the synthesis of the C and D rings of taxol are described, involving photolyses of α-methoxy ketones.Cis-fused oxetanols common to taxol are formed along with novel trans-fused oxetanols.Experiments bearing on the selectivity of this process as well as the mechanistic hypothesis are also described.