Toward the Synthesis of the Taxol C,D Ring System: Photolysis of α-Methoxy Ketones

DOI: 10.1016/S0040-4020(01)91212-8

Source and publish data:

Tetrahedron p. 7033 - 7048 (1992)

Update date:2022-08-02

Topics:

Authors:

Wender, Paul A.

Rawlins, David B.

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Article abstract of DOI:10.1016/S0040-4020(01)91212-8

Model systems for the synthesis of the C and D rings of taxol are described, involving photolyses of α-methoxy ketones.Cis-fused oxetanols common to taxol are formed along with novel trans-fused oxetanols.Experiments bearing on the selectivity of this process as well as the mechanistic hypothesis are also described.

Full text of DOI:10.1016/S0040-4020(01)91212-8

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