Synthesis of carbohydrate containing crown ethers and their application as catalysts in asymmetric Michael additions

Article abstract of DOI:10.1016/S0040-4020(01)89454-0

Synthesis of carbohydrate containing crown ethers tuned with steric and micro-environmental features and thier application as catalysts in the Michael addition of methyl phenylacetate to methyl acrylate to give a chiral products is reported. The mechanistic rationale of the asymmetric induction is discussed.