PhI(OAc)2-mediated synthesis of 6-(trifluoromethyl) phenanthridines by oxidative cyclization of 2-isocyanobiphenyls with CF 3SiMe3 under metal-free conditions

Article abstract of DOI:10.1021/ol4022589

A mild and efficient method for the synthesis of 6-(trifluoromethyl) phenanthridines through oxidative cyclization of 2-isocyanobiphenyls with CF₃SiMe₃ under metal-free conditions was developed. The reaction allows the direct formation of C-CF₃ bonds and rapid access to phenanthridine ring systems in one catalytic cycle.