Calcium entry blockers and activators: Conformational and structural determinants of dihydropyrimidine calcium channel modulators

DOI: 10.1021/jm00001a017

Source and publish data:

Journal of Medicinal Chemistry p. 119 - 129 (1995)

Update date:2022-08-05

Topics:

Authors:

Rovnyak Rovnyak

Kimball Kimball

Beyer Beyer

Cucinotta

DiMarco DiMarco

Gougoutas

Hedberg Hedberg

Malley Malley

McCarthy

Zhang Zhang

Moreland

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00001a017

Dihydropyrimidines 4, 6, and 15, uniquely designed to unambiguously establish structural and conformational determinants for DHP receptor occupation and for modulation of calcium channel function, were prepared and examined for calcium channel modulation.

Full text of DOI:10.1021/jm00001a017

Products guided by the article

Product name:2-<<3-nitro-2-<<5-<(tert-butyldimethylsilyl)oxy>pentyl>thio>phenyl>methylene>-3-oxobutanoic acid, 2-(trimethylsilyl)ethyl ester

Cas No:145457-73-4

R&D Labs maybe for 145457-73-4

Acros Pharmatech Limited

website:http://www.acrospharmatech.com

Contact:+1-3234804688

Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong
Jiaxing Anrui Material Technology Co., Ltd.

Contact:86-573-82651652 13305832579

Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
NOVASYNCS CO., LTD

Contact:0512-63006287

Address:no.88.YISHENG Road,etdz-WUJIANG,SUZHOU,CHINA
Shanghai Yuking Water Soluble Material Tech Co., Ltd

Contact:86-21-68286299

Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China

Relevant to this article

An efficient synthesis of 2-Alkylthio-5-phenylmethylidene-4H-imidazolin-4-ones

Doi:10.1081/SCC-120018686
(2003)
Doi:10.1021/jo01035a515
(1964)
An efficient synthesis of oxetanones from α,β-epoxy diazomethyl ketones

Doi:10.1016/S0040-4020(01)92288-4
(1992)
Doi:10.1063/1.442485
(1981)
Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR

Doi:10.1021/jm200803d
(2011)
Reductive and Catalytic Rearrangements of 2-Vinyl-1,3-Thiazetidines

Doi:10.1016/S0040-4020(01)89044-X
(1992)

Article Doi