New approaches to Corynanthe alkaloids involving the conjugate addition of dialkyl malonates to unsaturated thiolactams: Synthesis of (±)-3-epi-dihydrocorynantheol

DOI: 10.1016/S0040-4039(00)61004-3

Source and publish data:

Tetrahedron Letters p. 6633 - 6636 (1992)

Update date:2022-08-02

Topics:

Authors:

Gomez-Pardo

Desmaele

D'Angelo

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Article abstract of DOI:10.1016/S0040-4039(00)61004-3

Addition of dimethyl malonate to thiolactam 8 led to a mixture of Michael adducts 9 and 10 (6:1, respectively). Compound 9 has been converted in 4 steps into (±)-3-epi-dihydrocorynantheol 16.

Full text of DOI:10.1016/S0040-4039(00)61004-3

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