A new synthetic route to 1,5-benzothiazepines. Synthesis of derivatives of diltiazem

DOI: 10.1248/cpb.40.1986

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1986 - 1989 (1992)

Update date:2022-07-29

Topics:

Authors:

Harada Harada

Morimoto

Nagasawa

Takamura

Inoue Inoue

Oh-Ihsi Oh-Ihsi

Takeda Takeda

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Article abstract of DOI:10.1248/cpb.40.1986

Several derivatives of diltiazem (9a-c) have been synthesized from the oxamate (6) through the carbon-carbon ring closure of the sulfur-stabilized benzylic anion and the ester carbonyl group, followed by stereoselective reduction of the C₃-carb

Full text of DOI:10.1248/cpb.40.1986

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