Investigation of Stereoselectivities in the Coupling Reactions of 1-O-Methyl-3,5-di-O-p-toluoyl-2-deoxyribofuranoside with Purines and Pyrimidines

Article abstract of DOI:10.1016/S0040-4039(00)73064-4

Stereoselectivities in the coupling rection between 1-O-methyl-3,5-di-O-p-toluoyl-2-deoxyribofuranoside and suitably protected purine and pyrimidine derivatives have been examined in acetonitrile with varying equivalents of SnCl4.The best result in α-nucleoside formation was obtained when the coupling reaction was carried out in the presence of ten equivalents of SnCl4.