One-pot synthesis of (S)-4-isopropyl-2-p-toluene-4,5-dihydro-[1.2λ6,3]oxathiazole 2-Oxides: Efficient precursors of optically active sulfoximines

Article abstract of DOI:10.1016/S0040-4039(00)60906-1

The title compounds were prepared from p-toluenesulfinyl chloride and (S)-O-trimethylsilyl valinol without isolation of intermediates. Key step in the synthesis is the fluoride-induced cyclisation of sulfonimidoyl chlorides yielding the crystalline sulfon